Identical anthropometric characteristics of impaired fasting glucose combined with impaired glucose tolerance and newly diagnosed type 2 diabetes: anthropometric indicators to predict hyperglycaemia in a community-based prospective cohort study in southwest China.

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  • Additional Information
    • Source:
      Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
    • Subject Terms:
      Blood Glucose*; Anthropometry/*methods ; Diabetes Mellitus, Type 2/*epidemiology ; Glucose Intolerance/*epidemiology ; Hyperglycemia/*epidemiology; Adult ; Aged ; China/epidemiology ; Cohort Studies ; Comorbidity ; Diabetes Mellitus, Type 2/blood ; Fasting ; Female ; Follow-Up Studies ; Glucose Intolerance/blood ; Humans ; Hyperglycemia/blood ; Incidence ; Male ; Middle Aged ; Prediabetic State/blood ; Prediabetic State/epidemiology ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results
    • Abstract:
      Objectives: To assess the anthropometric characteristics of normoglycaemic individuals who subsequently developed hyperglycaemia, and to evaluate the validity of these measures to predict prediabetes and diabetes.
      Design: A community-based prospective cohort study.
      Participants: In total, 1885 residents with euglycaemia at baseline from six communities were enrolled.
      Setting: Sichuan, southwest China.
      Primary Outcome Measures: The incidences of prediabetes and diabetes were the primary outcomes.
      Methods: The waist-to-height ratio (WHtR), body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) of all participants were measured at baseline and during follow-up. A 75 g glucose oral glucose tolerance test was conducted at each survey.
      Results: During a median of 3.00 (IQR: 2.92-4.17) years follow-up, the cumulative incidence of isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), IFG combined with IGT (IFG+IGT), and newly diagnosed diabetes mellitus (NDDM) were 8.44%, 18.14%, 8.06% and 13.79%, respectively. WHtR, BMI, WC and WHR were significantly different among subjects who subsequently progressed to isolated IFG or IGT, IFG+IGT or NDDM (p<0.05). The anthropometric characteristics of IFG+IGT subjects were similar to those of the NDDM population (p>0.005). All the baseline anthropometric measurements were useful for the prediction of future prediabetes and NDDM (p<0.05). The optimal thresholds for the four measurements were calculated for the prediction of hyperglycaemia, with a WHtR value of 0.52 performing best to identify isolated IFG or IGT, IFG+IGT and NDDM.
      Conclusions: Anthropometric measures, especially WHtR, could be used to predict hyperglycaemia 3 years in advance. Distinct from isolated IFG and IGT, the individuals who developed combined IFG+IGT had identical anthropometric profiles to those who progressed to NDDM.
      Competing Interests: Competing interests: None declared.
      (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
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    • Contributed Indexing:
      Keywords: anthropometric measurements; impaired fasting glucose combined with impaired glucose tolerance; newly-diagnosed diabetes mellitus; pre-diabetes; waist-to-height ratio
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20180511 Date Completed: 20190517 Latest Revision: 20190517
    • Publication Date:
      20240628
    • Accession Number:
      PMC5942465
    • Accession Number:
      10.1136/bmjopen-2017-019735
    • Accession Number:
      29743321