A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Ericson MD;Ericson MD; Haskell-Luevano C; Haskell-Luevano C
  • Source:
    ACS chemical neuroscience [ACS Chem Neurosci] 2018 Jun 20; Vol. 9 (6), pp. 1235-1246. Date of Electronic Publication: 2018 May 11.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, D.C. : American Chemical Society
    • Subject Terms:
      Intracellular Signaling Peptides and Proteins/*genetics ; Neuropeptides/*genetics ; Polymorphism, Single Nucleotide/*genetics ; Receptors, G-Protein-Coupled/*genetics; Animals ; Humans ; Hypothalamic Hormones/genetics ; Hypothalamic Hormones/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Melanins/genetics ; Melanins/metabolism ; Neuropeptides/metabolism ; Orexins/genetics ; Orexins/metabolism ; Pituitary Hormones/genetics ; Pituitary Hormones/metabolism ; Receptors, G-Protein-Coupled/metabolism
    • Abstract:
      Many physiological pathways are involved in appetite, food intake, and the maintenance of energy homeostasis. In particular, neuropeptides within the central nervous system have been demonstrated to be critical signaling molecules for modulating appetite. Both anorexigenic (appetite-decreasing) and orexigenic (appetite-stimulating) neuropeptides have been described. The biological effects of these neuropeptides can be observed following central administration in animal models. This review focuses on single nucleotide polymorphisms (SNPs) in six orexigenic neuropeptides: agouti-related protein (AGRP), galanin, melanin concentrating hormone (MCH), neuropeptide Y (NPY), orexin A, and orexin B. Following a brief summary of the neuropeptides and their orexigenic activities, reports associating SNPs within the orexigenic neuropeptides to energy homeostasis, food intake, obesity, and BMI in humans are reviewed. Additionally, the NIH tool Variation Viewer was utilized to identify missense SNPs within the mature, biologically active neuropeptide sequences. For SNPs found through Variation Viewer, a concise discussion on relevant pharmacological structure-activity relationship studies for select SNPs is included. This review is meant to update reported orexigenic neuropeptide SNPs and demonstrate the potential utility of genomic sequence databases for finding SNPs that may result in altered receptor signaling for neuropeptide pathways associated with appetite.
    • References:
      PLoS Genet. 2017 May 10;13(5):e1006657. (PMID: 28489853)
      Endocrinology. 2006 Apr;147(4):1621-31. (PMID: 16384863)
      Nature. 1982 Apr 15;296(5858):659-60. (PMID: 6896083)
      Endocrinology. 1984 Jul;115(1):427-9. (PMID: 6547387)
      J Neuroendocrinol. 2008 Feb;20(2):199-206. (PMID: 18088361)
      Int J Pept Protein Res. 1991 Sep;38(3):267-72. (PMID: 1722197)
      Front Endocrinol (Lausanne). 2013 Feb 04;4:5. (PMID: 23382728)
      Br J Pharmacol. 1999 Sep;128(1):1-3. (PMID: 10498827)
      Diabetes Care. 2004 Feb;27(2):503-9. (PMID: 14747236)
      Front Endocrinol (Lausanne). 2013 Apr 22;4:49. (PMID: 23626585)
      Nat Genet. 1998 Oct;20(2):113-4. (PMID: 9771699)
      Neuron. 2001 May;30(2):345-54. (PMID: 11394998)
      J Biol Chem. 2017 May 5;292(18):7651-7661. (PMID: 28264929)
      Diabetes. 2007 May;56(5):1460-7. (PMID: 17325259)
      Proc Natl Acad Sci U S A. 1989 Dec;86(23):9588-91. (PMID: 2594786)
      Prog Mol Biol Transl Sci. 2013;114:147-91. (PMID: 23317785)
      Cell Mol Life Sci. 2008 Sep;65(17):2721-31. (PMID: 18470724)
      Nat Rev Drug Discov. 2003 Dec;2(12):986-98. (PMID: 14654797)
      J Nutr. 2005 Jun;135(6):1387-92. (PMID: 15930442)
      Nature. 1994 Dec 1;372(6505):425-32. (PMID: 7984236)
      Int J Obes (Lond). 2006 Apr;30(4):715-21. (PMID: 16130030)
      Pediatr Res. 2008 Feb;63(2):211-6. (PMID: 18091355)
      Regul Pept. 1993 Dec 10;49(2):133-44. (PMID: 7907802)
      N Engl J Med. 2016 Jul 21;375(3):240-6. (PMID: 27468060)
      Regul Pept. 2005 Apr 15;127(1-3):45-53. (PMID: 15680469)
      NCHS Data Brief. 2015 Nov;(219):1-8. (PMID: 26633046)
      Mol Pharmacol. 2000 Jul;58(1):217-25. (PMID: 10860944)
      Mol Endocrinol. 2001 Jan;15(1):164-71. (PMID: 11145747)
      Endocrinology. 1989 Sep;125(3):1660-5. (PMID: 2759038)
      Ann Nutr Metab. 2013;62(4):271-6. (PMID: 23652383)
      Diabetes. 2001 May;50(5):1206-10. (PMID: 11334428)
      Mol Cell Biol. 2002 Jul;22(14):5027-35. (PMID: 12077332)
      ACS Med Chem Lett. 2013 Dec 12;4(12):1224-1227. (PMID: 24707347)
      Nat Genet. 1998 Oct;20(2):111-2. (PMID: 9771698)
      Nature. 1996 May 30;381(6581):415-21. (PMID: 8632796)
      J Clin Endocrinol Metab. 2006 Nov;91(11):4664-8. (PMID: 16912140)
      J Biol Chem. 1993 Jun 25;268(18):13327-35. (PMID: 8514771)
      J Clin Invest. 2001 Feb;107(3):379-86. (PMID: 11160162)
      Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R47-52. (PMID: 10896863)
      Cell Metab. 2006 Feb;3(2):135-40. (PMID: 16459314)
      Cell Metab. 2009 Jan 7;9(1):64-76. (PMID: 19117547)
      Cell. 1999 Aug 20;98(4):437-51. (PMID: 10481909)
      Peptides. 1988 Sep-Oct;9(5):1183-9. (PMID: 2469064)
      Eur J Clin Nutr. 2010 Aug;64(8):868-72. (PMID: 20531438)
      Nature. 1983 Sep 22-28;305(5932):321-3. (PMID: 6621686)
      J Endocrinol. 1999 Mar;160(3):R7-12. (PMID: 10077743)
      Endocrinology. 1997 Jan;138(1):351-5. (PMID: 8977423)
      Life Sci. 1984 Dec 24;35(26):2635-42. (PMID: 6549039)
      Biochemistry. 1995 Sep 5;34(35):11227-36. (PMID: 7669781)
      Angiology. 2013 Jan;64(1):40-5. (PMID: 22308535)
      Cell. 1998 Feb 20;92(4):573-85. (PMID: 9491897)
      Genes Dev. 1997 Mar 1;11(5):593-602. (PMID: 9119224)
      ACS Chem Neurosci. 2018 May 16;9(5):1141-1151. (PMID: 29363944)
      ACS Chem Neurosci. 2018 Feb 21;9(2):320-327. (PMID: 28968061)
      ACS Chem Biol. 2012 Feb 17;7(2):395-402. (PMID: 22129136)
      Int J Obes (Lond). 2006 Oct;30(10):1522-8. (PMID: 16568137)
      Biochemistry. 2002 Jun 18;41(24):7565-72. (PMID: 12056887)
      Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):1063-9. (PMID: 17541984)
      Biochemistry. 2001 Dec 25;40(51):15520-7. (PMID: 11747427)
      Nature. 1996 Mar 21;380(6571):243-7. (PMID: 8637571)
      Peptides. 1989 Jul-Aug;10(4):757-61. (PMID: 2479930)
      Eur J Pharmacol. 1989 Apr 12;163(1):205-7. (PMID: 2472967)
      Neurosci Lett. 2005 Jun 3;380(3):239-42. (PMID: 15862893)
      Biochemistry. 2001 Aug 7;40(31):9379-86. (PMID: 11478907)
      J Med Chem. 1993 Nov 26;36(24):3802-8. (PMID: 8254609)
      Diabetes. 1999 Oct;48(10):2028-33. (PMID: 10512369)
      Pediatr Obes. 2012 Dec;7(6):453-60. (PMID: 22941950)
      Science. 1997 Oct 3;278(5335):135-8. (PMID: 9311920)
      Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7. (PMID: 9419374)
      Peptides. 2013 Jul;45:22-7. (PMID: 23624317)
      Mol Pharmacol. 1990 Oct;38(4):494-502. (PMID: 2172766)
      Nature. 1998 Mar 26;392(6674):398-401. (PMID: 9537324)
      Biochem Biophys Res Commun. 1997 Aug 28;237(3):629-31. (PMID: 9299416)
      Bioorg Med Chem Lett. 2001 Mar 12;11(5):737-40. (PMID: 11266181)
      Proc Natl Acad Sci U S A. 1984 Jul;81(14):4577-81. (PMID: 6589611)
      Pharmacol Rev. 2012 Jul;64(3):389-420. (PMID: 22759794)
      Peptides. 1999;20(9):1099-105. (PMID: 10499428)
      J Biol Chem. 1999 Jun 18;274(25):17771-6. (PMID: 10364220)
      Mol Endocrinol. 1990 Apr;4(4):632-7. (PMID: 2149166)
      Regul Pept. 1998 Sep 25;75-76:3-8. (PMID: 9802388)
      Neuropeptides. 1995 Sep;29(3):137-43. (PMID: 8538874)
      Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18632-7. (PMID: 16339312)
      N Engl J Med. 1986 Jan 23;314(4):193-8. (PMID: 3941707)
      Biochemistry. 1999 Jan 19;38(3):897-904. (PMID: 9893984)
      Cell. 2015 Mar 26;161(1):119-132. (PMID: 25815990)
      Proc Natl Acad Sci U S A. 1982 Sep;79(18):5485-9. (PMID: 6957876)
      Biochem Pharmacol. 2005 Jul 15;70(2):308-16. (PMID: 15927146)
      Endocrinology. 1991 Sep;129(3):1682-4. (PMID: 1714839)
      Nature. 1998 Dec 17;396(6712):670-4. (PMID: 9872314)
      Eur J Pharmacol. 2011 Jun 11;660(1):80-7. (PMID: 21199647)
      Bioorg Med Chem Lett. 2003 Jan 6;13(1):111-3. (PMID: 12467628)
      Int J Obes (Lond). 2014 May;38(5):724-9. (PMID: 23900445)
      Pharmacol Ther. 2007 Aug;115(2):177-207. (PMID: 17604107)
      BMC Med Genet. 2009 Jul 14;10:63. (PMID: 19602223)
      J Med Chem. 2004 Feb 26;47(5):1153-60. (PMID: 14971895)
      Neuroendocrinology. 2003 Jun;77(6):354-66. (PMID: 12845222)
      FEBS Lett. 1999 May 21;451(2):125-31. (PMID: 10371151)
      JAMA. 1986 Jul 4;256(1):51-4. (PMID: 3712713)
      Am J Med Genet B Neuropsychiatr Genet. 2014 Dec;165B(8):654-64. (PMID: 25228436)
      Br J Pharmacol. 1985 Sep;86(1):241-6. (PMID: 2413937)
      Alcohol. 2009 Dec;43(8):571-80. (PMID: 20004335)
      J Clin Endocrinol Metab. 2011 Dec;96(12):E2055-62. (PMID: 21937627)
      Pharmacogenet Genomics. 2015 Oct;25(10):501-10. (PMID: 26240981)
      FEBS Lett. 1983 Nov 28;164(1):124-8. (PMID: 6197320)
      Prog Mol Biol Transl Sci. 2016;140:97-129. (PMID: 27288827)
      Eur J Pharmacol. 1986 Mar 11;122(1):159-60. (PMID: 2420618)
      Nat Med. 1998 Dec;4(12):1434-7. (PMID: 9846584)
      Regul Pept. 2001 May 5;99(1):1-7. (PMID: 11257308)
      J Biol Chem. 2001 Apr 27;276(17):13554-62. (PMID: 11278733)
      Eur J Biochem. 1994 Nov 1;225(3):947-58. (PMID: 7957231)
      Endocrinology. 1998 Oct;139(10):4428-31. (PMID: 9751529)
      Cell Metab. 2005 Dec;2(6):421-7. (PMID: 16330327)
      J Clin Endocrinol Metab. 2013 Feb;98(2):736-42. (PMID: 23293326)
      Proc Assoc Am Physicians. 1998 May-Jun;110(3):171-82. (PMID: 9625524)
      Cell Metab. 2006 Feb;3(2):141-6. (PMID: 16459315)
      Balkan J Med Genet. 2013 Jun;16(1):63-8. (PMID: 24265586)
      J Pharmacol Exp Ther. 1999 May;289(2):1031-40. (PMID: 10215684)
      Int J Obes Relat Metab Disord. 2002 Oct;26(10):1289-95. (PMID: 12355323)
      Nat Genet. 1997 Nov;17(3):273-4. (PMID: 9354787)
      Brain Res. 1991 Sep 6;558(2):245-50. (PMID: 1723638)
    • Grant Information:
      F32 DK108402 United States DK NIDDK NIH HHS; R01 DK097838 United States DK NIDDK NIH HHS; R01 DK108893 United States DK NIDDK NIH HHS
    • Contributed Indexing:
      Keywords: GPCR; SNP; Single-nucleotide polymorphisms; agouti-related protein; galanin; hormone; melanocyte concentrating hormone; neuropeptide Y; orexin A; orexin B; peptide; pharmacogenomics; polypharmacology
    • Accession Number:
      0 (Hypothalamic Hormones)
      0 (Intracellular Signaling Peptides and Proteins)
      0 (Melanins)
      0 (Neuropeptides)
      0 (Orexins)
      0 (Pituitary Hormones)
      0 (Receptors, G-Protein-Coupled)
      67382-96-1 (melanin-concentrating hormone)
    • Publication Date:
      Date Created: 20180502 Date Completed: 20190611 Latest Revision: 20190622
    • Publication Date:
      20240829
    • Accession Number:
      PMC6042215
    • Accession Number:
      10.1021/acschemneuro.8b00151
    • Accession Number:
      29714060