Impaired function of cerebral parenchymal arterioles in experimental preeclampsia.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Johnson AC;Johnson AC; Cipolla MJ; Cipolla MJ; Cipolla MJ; Cipolla MJ
  • Source:
    Microvascular research [Microvasc Res] 2018 Sep; Vol. 119, pp. 64-72. Date of Electronic Publication: 2018 Apr 26.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0165035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9319 (Electronic) Linking ISSN: 00262862 NLM ISO Abbreviation: Microvasc Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Cerebrovascular Circulation* ; Vasoconstriction* ; Vasodilation*; Arterioles/*physiopathology ; Basal Ganglia/*blood supply ; Parenchymal Tissue/*blood supply ; Pre-Eclampsia/*physiopathology ; White Matter/*blood supply; Animals ; Arterioles/metabolism ; Biomarkers/blood ; Blood Pressure ; Disease Models, Animal ; Female ; Inflammation Mediators/blood ; Intermediate-Conductance Calcium-Activated Potassium Channels/metabolism ; Oxidative Stress ; Potassium Channels, Inwardly Rectifying/metabolism ; Pre-Eclampsia/blood ; Pregnancy ; Rats, Sprague-Dawley ; Vascular Remodeling
    • Abstract:
      Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arterioles (PAs) would be impaired during PE. Using a high cholesterol diet to induce experimental PE in rats (ePE), we studied the function and structure of isolated and pressurized PAs supplying frontoparietal white matter (WM) tracts and cortex and compared to normal pregnant (Preg) and nonpregnant (Nonpreg) Sprague Dawley rats (n = 8/group). Myogenic reactivity and tone were similar between groups; however, constriction to intermediate-conductance calcium-activated potassium (IK) channel inhibition was diminished and dilation to inward-rectifying K + (K IR ) channel activation was impaired in PAs from ePE rats, suggesting altered ion channel function. Conducted vasodilation was significantly delayed in response to 12 mM KCl, but not 10 μM adenosine, in PAs from ePE rats versus Preg and Nonpreg rats (940 ± 300 ms vs. 70 ± 50 ms and 370 ± 90 ms; p < 0.05). Overall, dysfunction of PAs supplying frontoparietal WM and gray matter was present in ePE. If persistent these changes could potentiate neuronal injury that over time could contribute to WM lesions and early-onset cognitive decline.
      (Copyright © 2018 Elsevier Inc. All rights reserved.)
    • References:
      Stroke. 2006 Jun;37(6):1391-8. (PMID: 16627790)
      J Appl Physiol (1985). 2006 Jan;100(1):318-27. (PMID: 16357085)
      Hypertension. 2009 Feb;53(2):270-7. (PMID: 19104003)
      Reprod Sci. 2013 Sep;20(9):1046-54. (PMID: 23420820)
      J Cereb Blood Flow Metab. 2016 Jul;36(7):1195-201. (PMID: 27052838)
      J Cereb Blood Flow Metab. 2013 May;33(5):649-56. (PMID: 23443170)
      Physiol Res. 2006;55(5):491-500. (PMID: 16343047)
      Obstet Gynecol. 2001 Apr;97(4):533-8. (PMID: 11275024)
      Lancet Neurol. 2010 Jul;9(7):689-701. (PMID: 20610345)
      Am J Obstet Gynecol. 2007 Oct;197(4):365.e1-6. (PMID: 17904961)
      Stroke. 2009 Apr;40(4):1451-7. (PMID: 19246694)
      Metabolism. 1998 Oct;47(10):1281-8. (PMID: 9781635)
      Atherosclerosis. 2002 Jun;162(2):425-32. (PMID: 11996963)
      J Appl Physiol (1985). 2011 Feb;110(2):329-39. (PMID: 21071591)
      Pregnancy Hypertens. 2013 Oct;3(4):227-34. (PMID: 26103801)
      Biomed Res Int. 2017;2017:9372050. (PMID: 28316994)
      J Cardiovasc Pharmacol. 2003 Mar;41(3):444-51. (PMID: 12605023)
      Stroke. 2008 Oct;39(10):2712-9. (PMID: 18635849)
      J Appl Physiol (1985). 2006 Jan;100(1):328-35. (PMID: 16357086)
      Reprod Sci. 2013 Apr;20(4):391-9. (PMID: 23171682)
      Ultrasound Med Biol. 2009 Jan;35(1):1-7. (PMID: 18845379)
      FASEB J. 2013 Mar;27(3):1254-63. (PMID: 23230281)
      Nat Neurosci. 2017 May;20(5):717-726. (PMID: 28319610)
      FASEB J. 2011 Sep;25(9):3229-39. (PMID: 21602449)
      Stroke. 2014 Sep;45(9):2792-4. (PMID: 25034711)
      Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3811-6. (PMID: 20133576)
      Proc Natl Acad Sci U S A. 2014 May 20;111(20):7462-7. (PMID: 24808139)
      Neurology. 2017 Mar 28;88(13):1256-1264. (PMID: 28235810)
      J Vasc Res. 2014;51(4):290-304. (PMID: 25300258)
      Hypertension. 2012 Sep;60(3):705-11. (PMID: 22824983)
      Microcirculation. 2015 Apr;22(3):183-96. (PMID: 25641345)
      Hum Reprod Update. 1998 Jan-Feb;4(1):25-42. (PMID: 9622411)
      BJOG. 2012 Aug;119(9):1117-22. (PMID: 22703533)
      Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22290-5. (PMID: 21135230)
      Minerva Ginecol. 2012 Aug;64(4):309-20. (PMID: 22728575)
      J Hypertens. 2012 Jan;30(1):17-33. (PMID: 22134391)
      Sao Paulo Med J. 2011 Mar;129(2):73-6. (PMID: 21603783)
      J Clin Exp Neuropsychol. 2016;38(5):585-98. (PMID: 26949992)
      J Cereb Blood Flow Metab. 2017 Aug;37(8):2857-2869. (PMID: 27815419)
      Pharmacol Ther. 2002 Jul;95(1):89-100. (PMID: 12163130)
      Circ J. 2009 Nov;73(11):1993-9. (PMID: 19801851)
      Physiology (Bethesda). 2006 Feb;21:69-78. (PMID: 16443824)
      Am J Obstet Gynecol. 2006 Jul;195(1):186-91. (PMID: 16579917)
      Neuron. 2013 Nov 20;80(4):844-66. (PMID: 24267647)
      Obstet Gynecol. 2014 Apr;123(4):790-5. (PMID: 24785606)
      J Cardiovasc Pharmacol. 2014 Jan;63(1):33-9. (PMID: 24084218)
    • Grant Information:
      R01 NS045940 United States NS NINDS NIH HHS; R01 NS108455 United States NS NINDS NIH HHS
    • Contributed Indexing:
      Keywords: Cerebral arterioles; Cerebrovascular dysfunction; Conducted vasodilation; Preeclampsia; Pregnancy
    • Accession Number:
      0 (Biomarkers)
      0 (Inflammation Mediators)
      0 (Intermediate-Conductance Calcium-Activated Potassium Channels)
      0 (Potassium Channels, Inwardly Rectifying)
    • Publication Date:
      Date Created: 20180430 Date Completed: 20190128 Latest Revision: 20240827
    • Publication Date:
      20240827
    • Accession Number:
      PMC6005767
    • Accession Number:
      10.1016/j.mvr.2018.04.007
    • Accession Number:
      29705580