FoxP2 Expression in a Highly Vocal Teleost Fish with Comparisons to Tetrapods.

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  • Author(s): Pengra IGG; Marchaterre MA; Bass AH
  • Source:
    Brain, behavior and evolution [Brain Behav Evol] 2018; Vol. 91 (2), pp. 82-96. Date of Electronic Publication: 2018 Apr 19.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 0151620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9743 (Electronic) Linking ISSN: 00068977 NLM ISO Abbreviation: Brain Behav Evol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, New York, Karger.
    • Subject Terms:
      Vocalization, Animal*; Amphibians/*metabolism ; Brain/*metabolism ; Fishes/*metabolism ; Forkhead Transcription Factors/*biosynthesis ; Mammals/*metabolism ; Reptiles/*metabolism; Animals ; Biological Evolution ; Female ; Male
    • Abstract:
      Motivated by studies of speech deficits in humans, several studies over the past two decades have investigated the potential role of a forkhead domain transcription factor, FoxP2, in the central control of acoustic signaling/vocalization among vertebrates. Comparative neuroanatomical studies that mainly include mammalian and avian species have mapped the distribution of FoxP2 expression in multiple brain regions that imply a greater functional significance beyond vocalization that might be shared broadly across vertebrate lineages. To date, reports for teleost fish have been limited in number and scope to nonvocal species. Here, we map the neuroanatomical distribution of FoxP2 mRNA expression in a highly vocal teleost, the plainfin midshipman (Porichthys notatus). We report an extensive overlap between FoxP2 expression and vocal, auditory, and steroid-signaling systems with robust expression at multiple sites in the telencephalon, the preoptic area, the diencephalon, and the midbrain. Label was far more restricted in the hindbrain though robust in one region of the reticular formation. A comparison with other teleosts and tetrapods suggests an evolutionarily conserved FoxP2 phenotype important to vocal-acoustic and, more broadly, sensorimotor function among vertebrates.
      (© 2018 S. Karger AG, Basel.)
    • Contributed Indexing:
      Keywords: Androgen receptor; Estrogen receptor; FoxP2; Teleost fish
    • Accession Number:
      0 (Forkhead Transcription Factors)
    • Publication Date:
      Date Created: 20180420 Date Completed: 20190325 Latest Revision: 20190325
    • Publication Date:
      20231215
    • Accession Number:
      10.1159/000487793
    • Accession Number:
      29672280