Folate Nutrition Status in Mothers of the Boston Birth Cohort, Sample of a US Urban Low-Income Population.

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  • Author(s): Cheng TL;Cheng TL; Mistry KB; Mistry KB; Wang G; Wang G; Zuckerman B; Zuckerman B; Wang X; Wang X
  • Source:
    American journal of public health [Am J Public Health] 2018 Jun; Vol. 108 (6), pp. 799-807. Date of Electronic Publication: 2018 Apr 19.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Public Health Association Country of Publication: United States NLM ID: 1254074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-0048 (Electronic) Linking ISSN: 00900036 NLM ISO Abbreviation: Am J Public Health Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : American Public Health Association
      Original Publication: New York [etc.]
    • Subject Terms:
      Folic Acid/*blood ; Folic Acid Deficiency/*epidemiology ; Nutritional Status/*physiology ; Pregnancy Complications/*epidemiology; Adult ; Boston/epidemiology ; Female ; Humans ; Poverty ; Pregnancy ; Retrospective Studies ; Young Adult
    • Abstract:
      Objectives: To examine maternal folic acid supplementation and plasma folate concentrations in the Boston Birth Cohort, a predominantly urban, low-income, minority population in Boston, Massachusetts.
      Methods: This report includes 7612 mothers with singleton live births (3829 Black, 2023 Hispanic, 865 White, and 895 others) enrolled in the Boston Birth Cohort at the Boston Medical Center, during 1999 to 2014. Folic acid supplementation during preconception and each trimester was obtained via interview questionnaire. In a subset (n = 2598), maternal plasma folate concentrations were measured in blood samples drawn within a few days of delivery.
      Results: The percentage of mothers taking folic acid supplementation almost daily during preconception and the first, second, and third trimesters were 4.3%, 55.9%, 59.4%, and 58.0%, respectively. Most striking, we observed a wide range of maternal plasma folate concentrations, with approximately 11% insufficient (< 13.4 nmol/L) and 23% elevated (> 45.3 nmol/L).
      Conclusions: Findings indicate that fewer than 5% of mothers in the Boston Birth Cohort started folic acid supplements before pregnancy, and approximately one third of mothers had either too low or too high plasma folate levels, which may have important health consequences on both the mother and the child.
    • References:
      Birth Defects Res A Clin Mol Teratol. 2015 Jun;103(6):517-26. (PMID: 25884850)
      Clin Chem Lab Med. 2013 Mar 1;51(3):555-69. (PMID: 23449524)
      Public Health Rev. 2000;28(1-4):117-45. (PMID: 11411265)
      J Nutr. 2012 May;142(5):886-93. (PMID: 22437563)
      Birth Defects Res. 2017 Jan 20;109 (1):38-48. (PMID: 27905191)
      Mol Genet Metab. 2000 May;70(1):45-52. (PMID: 10833330)
      Br J Nutr. 2015 Jun 28;113(12 ):1965-77. (PMID: 25917925)
      N Engl J Med. 1999 Nov 11;341(20):1485-90. (PMID: 10559448)
      JAMA Pediatr. 2016 Aug 1;170(8):e160845. (PMID: 27295011)
      BMC Pregnancy Childbirth. 2016 Aug 05;16(1):210. (PMID: 27496139)
      JAMA. 2017 Jan 10;317(2):144-145. (PMID: 28097344)
      Eur J Nutr. 2017 Feb;56(1):65-75. (PMID: 26497537)
      Int J Epidemiol. 2010 Apr;39 Suppl 1:i110-21. (PMID: 20348114)
      J Nutr. 2006 Jan;136(1):153-8. (PMID: 16365075)
      Am J Hypertens. 2017 May 1;30(5):532-540. (PMID: 28338750)
      Pediatrics. 1999 Aug;104(2 Pt 1):325-7. (PMID: 10429019)
      N Engl J Med. 1992 Dec 24;327(26):1832-5. (PMID: 1307234)
      Paediatr Perinat Epidemiol. 2018 Jan;32(1):100-111. (PMID: 28984369)
      Am J Respir Crit Care Med. 2017 Jan 15;195(2):221-228. (PMID: 27518161)
      Matern Child Nutr. 2016 Jan;12 (1):39-50. (PMID: 24934272)
      Brain Sci. 2017 Nov 10;7(11):null. (PMID: 29125540)
      J Obstet Gynecol Neonatal Nurs. 2007 Jul-Aug;36(4):335-41. (PMID: 17594408)
      JAMA. 2002 Jan 9;287(2):195-202. (PMID: 11779261)
      Birth Defects Res A Clin Mol Teratol. 2014 Jun;100(6):472-82. (PMID: 24706436)
      JAMA Pediatr. 2014 Nov;168(11):e142611. (PMID: 25365251)
      MMWR Morb Mortal Wkly Rep. 2010 Aug 13;59(31):980-4. (PMID: 20703205)
      Am J Public Health. 2014 Sep;104(9):e14-23. (PMID: 25033129)
      JAMA. 2017 Jan 10;317(2):183-189. (PMID: 28097362)
      JAMA. 2014 Feb 12;311(6):587-96. (PMID: 24519298)
      JAMA Pediatr. 2017 Jul 1;171(7):709-710. (PMID: 28558096)
    • Grant Information:
      R21 HD066471 United States HD NICHD NIH HHS; U01 AI090727 United States AI NIAID NIH HHS; R01 HD041702 United States HD NICHD NIH HHS; R21 AI079872 United States AI NIAID NIH HHS; R21 ES011666 United States ES NIEHS NIH HHS; R01 HD086013 United States HD NICHD NIH HHS
    • Accession Number:
      935E97BOY8 (Folic Acid)
    • Publication Date:
      Date Created: 20180420 Date Completed: 20190705 Latest Revision: 20190705
    • Publication Date:
      20240829
    • Accession Number:
      PMC5944873
    • Accession Number:
      10.2105/AJPH.2018.304355
    • Accession Number:
      29672150