Hormonal and metabolic changes during hypothermic coronary artery bypass surgery in diabetic and non-diabetic subjects.

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  • Additional Information
    • Source:
      Publisher: Blackwell Science Country of Publication: England NLM ID: 8500858 Publication Model: Print Cited Medium: Print ISSN: 0742-3071 (Print) Linking ISSN: 07423071 NLM ISO Abbreviation: Diabet Med Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Blackwell Science
      Original Publication: Chichester [Sussex, England] ; New York : Wiley, [c1984-
    • Subject Terms:
      Coronary Artery Bypass* ; Hypothermia, Induced*; Diabetes Mellitus, Type 2/*blood ; Glucose/*pharmacology ; Hormones/*blood; Blood Glucose/metabolism ; Catecholamines/blood ; Glucagon/blood ; Humans ; Hydrocortisone/blood ; Insulin/blood ; Intraoperative Period
    • Abstract:
      Hormonal and metabolic responses to hypothermic coronary artery bypass grafting (CABG) were studied in three groups: 8 non-diabetic patients, 8 patients with non-insulin-dependent diabetes mellitus (NIDDM) given a glucose pump priming solution and 8 NIDDM patients given a non-glucose infusion. There were no significant differences in stress hormone responses between NIDDM and non-diabetic patients, with adrenaline concentrations rising 10-fold, noradrenaline 4-fold and cortisol 2 to 3-fold. Glucagon rose significantly during bypass only in the NIDDM patients who did not receive a glucose prime. Comparable marked hyperglycaemia was seen in both glucose primed groups during bypass and exclusion of glucose from the prime in NIDDM patients prevented this major rise. Postoperatively, the rise in insulin in the glucose primed NIDDM patients contrasted with the slower rise in the non-glucose primed NIDDM patients who were also hyperglycaemic by this stage. Perioperative hyperglycaemia in NIDDM patients undergoing CABG can be prevented by using a non-glucose priming solution and by giving insulin infusion, particularly postoperatively.
    • Accession Number:
      0 (Blood Glucose)
      0 (Catecholamines)
      0 (Hormones)
      0 (Insulin)
      9007-92-5 (Glucagon)
      IY9XDZ35W2 (Glucose)
      WI4X0X7BPJ (Hydrocortisone)
    • Publication Date:
      Date Created: 19880101 Date Completed: 19880415 Latest Revision: 20190828
    • Publication Date:
      20221213
    • Accession Number:
      10.1111/j.1464-5491.1988.tb00940.x
    • Accession Number:
      2964328