Conjugated linoleic acid enriched skim milk prepared with Lactobacillus fermentum DDHI27 endorsed antiobesity in mice.

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  • Author(s): Dahiya DK;Dahiya DK; Puniya AK; Puniya AK; Puniya AK
  • Source:
    Future microbiology [Future Microbiol] 2018 Jul; Vol. 13, pp. 1007-1020. Date of Electronic Publication: 2018 Apr 10.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278120 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-0921 (Electronic) Linking ISSN: 17460913 NLM ISO Abbreviation: Future Microbiol Subsets: MEDLINE
    • Publication Information:
      Publication: 2024- : [Milton Park, Oxfordshire] : Taylor & Francis
      Original Publication: London : Future Medicine
    • Subject Terms:
      Diet Therapy/*methods ; Limosilactobacillus fermentum/*metabolism ; Linoleic Acids, Conjugated/*metabolism ; Milk/*chemistry ; Milk/*microbiology ; Obesity/*therapy; Animals ; Body Weight ; Disease Models, Animal ; Lipids/blood ; Mice, Inbred C57BL ; Mice, Obese ; Treatment Outcome
    • Abstract:
      Aim: This study evaluated the antiobesity effect of skim milk prepared with conjugated linoleic acid producing probiotic Lactobacillus fermentum DDHI27 (PCLA).
      Materials & Methods: C57BL/6 J mice were divided into five groups, and different obesity-associated parameters were studied.
      Results: PCLA supplementation alleviated body weight, epididymal and mesenteric fats and improves lipid profiles. Significant ameliorations in leptin, blood glucose, hepatic steatosis and reduction in adipocytes size were also observed. Additionally, feeding also led to positive alterations in the adipogenesis transcription factors and key lipogenesis genes. Improvement in the gut microbiota dysbiosis was also revealed.
      Conclusion: Results inferred that PCLA exerted an antiobesity effect in diet-induced obese mice and may be further developed in the functional foods for the management of obesity.
    • Contributed Indexing:
      Keywords: ACC; C/EBPα; FAS; PPARγ; SERBP-1c; UCP-2; conjugated linoleic acid; functional foods; liver steatosis; skim milk
    • Accession Number:
      0 (Linoleic Acids, Conjugated)
      0 (Lipids)
    • Publication Date:
      Date Created: 20180411 Date Completed: 20181217 Latest Revision: 20221207
    • Publication Date:
      20250114
    • Accession Number:
      10.2217/fmb-2017-0280
    • Accession Number:
      29633859