The prognosis significance and application value of peritoneal elastic lamina invasion in colon cancer.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Adenocarcinoma/*secondary ; Colonic Neoplasms/*pathology ; Elastic Tissue/*pathology ; Peritoneum/*pathology ; Serous Membrane/*pathology; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Colonic Neoplasms/surgery ; Feasibility Studies ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Retrospective Studies

Objectives: The aims of this study were to evaluate the associations between peritoneal elastic lamina invasion (ELI) and the clinicopathological prognostic factors of colon cancer, to evaluate the feasibility of ELI with use of an elastic stain to help diagnose serosal invasion of colon cancer in routine practice, so as to help us to provide a more accurate estimate for prognosis and stage of patients and a marker for postoperative treatment.
Methods: 254 cases with colon cancer were included in the study. According to the presence of elastic lamina (EL) and elastic lamina invasion (ELI), all cases were divided into four groups: pT3 EL negative (pT3 EL (-)), pT3 ELI positive (pT3 ELI (+)), pT3 ELI negative (pT3 ELI (-)) and pT4a. Statistical analysis was used to analyze the relationship between elastic lamina invasion and other established adverse histologic features.
Results: The EL and ELI positive rates were 81.5% and 42.1% respectively. There were significant differences in mph node metastasis, venous invasion and tumor buds between pT3 ELI (-) and pT3 ELI (+), pT3 ELI (-) and pT4a. There was no significant difference in same factors between pT3 ELI (+) and pT4a. In pT3 stage, there were significant differences in lymph node metastasis, perineural invasion and tumor buds between EL (-) and ELI (+). There were no significant differences in same factors between EL (-) and ELI (-). EL was detected less frequently in right-sided tumors compared with left-sided tumors.
Conclusions: ELI might be the prognostic factors of colon cancer with II stage and might be the marker of postoperative adjuvant chemotherapy. Patients with pT3 ELI (+) might have similar prognosis to patients with pT4a. For patients with pT3 colon cancer, EL(-) might have similar prognosis as ELI (-) and might take the same therapy. In addition, the right half colon EL positive rate was lower than the left colon. Elastic staining might be a useful tool to help determine the invasive depth and stage of colon cancer.

J Anat. 1991 Aug;177:41-6. (PMID: 1769897)
Br J Surg. 2006 Jul;93(7):866-71. (PMID: 16622901)
Hum Pathol. 2013 Dec;44(12):2696-705. (PMID: 24074534)
Curr Opin Genet Dev. 2008 Feb;18(1):27-34. (PMID: 18282701)
Cancer. 2001 Sep 15;92(6):1435-43. (PMID: 11745220)
Dis Colon Rectum. 2004 Apr;47(4):467-73. (PMID: 14994112)
Int J Clin Oncol. 2012 Feb;17(1):1-29. (PMID: 22002491)
Cancer. 1995 Aug 15;76(4):564-71. (PMID: 8625148)
Am J Surg Pathol. 2013 Oct;37(10):1565-70. (PMID: 23774172)
Aust N Z J Surg. 1983 Jun;53(3):211-21. (PMID: 6309132)
Arch Pathol Lab Med. 2010 Jun;134(6):837-52. (PMID: 20524862)
Histopathology. 2006 Oct;49(4):435-7. (PMID: 16978212)
Am J Clin Pathol. 2003 Jan;119(1):108-13. (PMID: 12520705)
Am J Surg Pathol. 2010 Sep;34(9):1351-60. (PMID: 20716999)
Gut. 2002 Jul;51(1):65-9. (PMID: 12077094)
Cancers (Basel). 2011 Jan 04;3(1):164-81. (PMID: 24212611)
Histopathology. 2005 Aug;47(2):123-31. (PMID: 16045772)
Cancer. 1987 Aug 15;60(4):852-7. (PMID: 3594403)
J Thorac Oncol. 2008 Dec;3(12):1384-90. (PMID: 19057261)
Gastroenterology. 1997 Apr;112(4):1096-102. (PMID: 9097991)

Date Created: 20180410 Date Completed: 20180724 Latest Revision: 20181114

20231215

PMC5890982

10.1371/journal.pone.0194804

29630617