Natural history of myocardial deformation in children, adolescents, and young adults exposed to anthracyclines: Systematic review and meta-analysis.

Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8511187 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8175 (Electronic) Linking ISSN: 07422822 NLM ISO Abbreviation: Echocardiography Subsets: MEDLINE

Publication: Hoboken, NJ : Wiley-Blackwell
Original Publication: Mount Kisco, N.Y. : Futura Pub. Co., [c1984-

Heart Ventricles*/diagnostic imaging ; Heart Ventricles*/drug effects ; Heart Ventricles*/physiopathology ; Ventricular Dysfunction*/chemically induced ; Ventricular Dysfunction*/diagnosis ; Ventricular Dysfunction*/physiopathology; Anthracyclines/*adverse effects ; Echocardiography, Three-Dimensional/*methods ; Neoplasms/*drug therapy; Adolescent ; Adult ; Cardiotoxicity ; Child ; Humans ; Young Adult

Objective: Anthracyclines are widely used to treat solid and hematologic malignancies, but are known to cause cardiotoxicity. As more childhood cancer survivors reach adulthood due to improvements in oncologic treatments, they become susceptible to late and progressive anthracycline-induced cardiotoxicity. Nonetheless, diagnostic criteria for early detection of cardiac dysfunction are not well defined in children, adolescent, and young adults (CAYA, ages 1-40 years). We present a natural history of the changes in myocardial deformation in CAYA patients after anthracycline therapy.
Methods: We performed a literature review search between 2001 and 2016 using PubMed with the following search terms: strain (or deformation), torsion (or twist), children (or adolescent or young adult), cardiotoxicity (or dysfunction), and anthracyclines (or doxorubicin). A total of 23 articles were reviewed. Fourteen articles were incorporated in the meta-analysis.
Results: Strain abnormalities are observed at both short-term and long-term follow-up. Global longitudinal strain (GLS) abnormalities are common during or early after chemotherapy, whereas changes in global circumferential strain (GCS) are more significant and consistent on long-term follow-up. Although global radial strain and torsional parameters are also often abnormal late after chemotherapy, there are few studies evaluating these parameters.
Conclusion: There are significant abnormalities in GLS and GCS following anthracycline therapy acutely and late after treatment. The prognostic value of these strain abnormalities warrants further investigation.
(© 2018 Wiley Periodicals, Inc.)

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UL1 TR000124 United States TR NCATS NIH HHS; UL1 TR001881 United States TR NCATS NIH HHS

Keywords: cardiac toxicity; myocardial strain; transthoracic echocardiography

0 (Anthracyclines)

Date Created: 20180401 Date Completed: 20181105 Latest Revision: 20240918

20240918

PMC6544758

10.1111/echo.13871

29603386