Fever Burden and Health-Related Quality of Life After Intracerebral Hemorrhage.

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  • Additional Information
    • Source:
      Publisher: Humana Press Country of Publication: United States NLM ID: 101156086 Publication Model: Print Cited Medium: Internet ISSN: 1556-0961 (Electronic) Linking ISSN: 15416933 NLM ISO Abbreviation: Neurocrit Care Subsets: MEDLINE
    • Publication Information:
      Original Publication: Totowa, NJ : Humana Press, c2004-
    • Subject Terms:
      Outcome Assessment, Health Care* ; Quality of Life*; Cerebral Hemorrhage/*complications ; Cognitive Dysfunction/*etiology ; Fever/*etiology; Aged ; Cerebral Hemorrhage/therapy ; Female ; Fever/therapy ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies
    • Abstract:
      Background: Fever is associated with worse functional outcomes after intracerebral hemorrhage (ICH); however, there are few prospective data to quantify the relationship with health-related quality of life (HRQoL). We tested the hypothesis that increased burden of fever is independently associated with decreased HRQoL at follow-up.
      Methods: In this prospective observational cohort study of 106 ICH patients admitted to a tertiary care hospital between 2011 and 2015, we recorded the highest core temperature each calendar day for 14 days after ICH onset. Fever burden was defined as the number of days with a fever ≥ 100.4 °F (38 °C). HRQoL outcomes were measured with Neuro-QoL domains of Cognitive Function and Mobility at 28 days, 3 months, and 1 year. Results were analyzed using mixed effects regression analysis.
      Results: Each additional day with a fever was independently associated with lower Mobility HRQoL (T-score - 0.9, [- 1.6 to - 0.2]; p = 0.01) and Cognitive Function HRQoL (T-score - 1.3 [- 2.0 to - 0.6]; p = 0.001) after correction for National Institutes of Health Stroke Scale score on admission, age, and time to follow-up.
      Conclusions: Each additional day with a fever was predictive of worse HRQoL domains of Cognitive Function and Mobility after ICH up to 1 year. These data extend previous evidence on the negative association of fever and functional outcomes to the domains of Cognitive Function and Mobility HRQoL. HRQoL outcomes may be a sensitive and powerful way to measure the efficacy of fever control in future research.
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    • Grant Information:
      KL2TR001424 United States TR NCATS NIH HHS; K23NS092975 United States NH NIH HHS; HS023437 International Agency for Healthcare Research and Quality; L30NS098427 United States NH NIH HHS; UL1TR001422 United States TR NCATS NIH HHS; L30NS080176 United States NH NIH HHS
    • Contributed Indexing:
      Keywords: Brain; Cerebral hemorrhage; Cognition; Critical care; Fever; Quality of life
    • Publication Date:
      Date Created: 20180331 Date Completed: 20191003 Latest Revision: 20191210
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s12028-018-0523-y
    • Accession Number:
      29600341