Case Fatality Rate of Enteric Fever in Endemic Countries: A Systematic Review and Meta-analysis.

Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE

Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: Chicago, IL : The University of Chicago Press, c1992-

Endemic Diseases*; Paratyphoid Fever/*mortality ; Typhoid Fever/*mortality; Africa/epidemiology ; Anti-Bacterial Agents/pharmacology ; Asia/epidemiology ; Humans ; Salmonella paratyphi A/drug effects ; Salmonella paratyphi A/isolation & purification ; Salmonella typhi/drug effects ; Salmonella typhi/isolation & purification

Enteric fever is a febrile illness, occurring mostly in Asia and Africa, which can present as a severe and possibly fatal disease. Currently, a case fatality rate (CFR) of 1% is assumed when evaluating the global burden of enteric fever. Until now, no meta-analysis has been conducted to summarize mortality from enteric fever. Therefore, we conducted a systematic review and meta-analysis to aggregate all available evidence. We estimated an overall CFR of 2.49% (95% confidence interval, 1.65%-3.75%; n = 44), and a CFR in hospitalized patients of 4.45% (2.85%-6.88%; n = 21 of 44). There was considerably heterogeneity in estimates of the CFR from individual studies. Neither age nor antimicrobial resistance were significant prognostic factors, but limited data were available for these analyses. The combined estimate of the CFR for enteric fever is higher than previously estimated, and the evaluation of prognostic factors, including antimicrobial resistance, urgently requires more data.

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0 (Anti-Bacterial Agents)

Date Created: 20180310 Date Completed: 20191031 Latest Revision: 20240329

20240329

PMC6070077

10.1093/cid/ciy190

29522159