IL10 promoter haplotypes may contribute to altered cytokine expression and systemic inflammation in celiac disease.

Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE

Original Publication: Orlando, FL : Academic Press, c1999-

Celiac Disease/*immunology ; Cytokines/*immunology ; Haplotypes/*immunology ; Inflammation/*immunology ; Interleukin-10/*immunology ; Promoter Regions, Genetic/*immunology; Adolescent ; Celiac Disease/blood ; Celiac Disease/genetics ; Child ; Child, Preschool ; Cytokines/blood ; Cytokines/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Glutens/immunology ; Haplotypes/genetics ; Humans ; Inflammation/blood ; Inflammation/genetics ; Interleukin-10/blood ; Interleukin-10/genetics ; Interleukin-17/blood ; Interleukin-17/genetics ; Interleukin-17/immunology ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic/genetics

Celiac disease (CD) is an autoimmune/inflammatory condition triggered by dietary gluten intake in genetically predisposed individuals. Though associations with MHC class II HLA-DQ2 or -DQ8 are the primary and necessary genetic predisposition for CD, >97% of genetically predisposed individuals never develop CD. Cytokines were measured in the serum of CD patients and controls. Possible associations with IL10 promoter variants were investigated. Cytokine expression from PBMCs was monitored in response to gluten exposure, or CD3/TCR complex stimulation in the absence or presence of recombinant IL-10. Serum cytokines varied between patients with CD at the time of diagnosis, after dietary elimination of gluten, and healthy controls. Serum IL-17A reflected disease activity. Reduced IL-10 serum levels and altered IL-10 expression by PBMCs coincided with IL10 promoter haplotypes that encode for "low" IL-10 expression (ATA). Increased prevalence of ATA IL10 promoter haplotypes and subsequently reduced IL-10 expression may be an immunological cofactor in individuals genetically predisposed for the development of CD. Resulting cytokine imbalances may be utilized as disease biomarkers in CD.
(Copyright © 2018 Elsevier Inc. All rights reserved.)

0 (Cytokines)
0 (Interleukin-17)
130068-27-8 (Interleukin-10)
8002-80-0 (Glutens)

Date Created: 20180227 Date Completed: 20190701 Latest Revision: 20190701

20240829

10.1016/j.clim.2018.02.010

29481982