Neuropathologic findings in idiopathic opsoclonus and myoclonus. Their similarity to those in paraneoplastic cerebellar cortical degeneration.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Hunter S; Kooistra C
  • Source:
    Journal of clinical neuro-ophthalmology [J Clin Neuroophthalmol] 1986 Dec; Vol. 6 (4), pp. 236-41.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Raven Press Country of Publication: United States NLM ID: 8109051 Publication Model: Print Cited Medium: Print ISSN: 0272-846X (Print) Linking ISSN: 0272846X NLM ISO Abbreviation: J Clin Neuroophthalmol Subsets: MEDLINE
    • Publication Information:
      Publication: New York Ny : Raven Press
      Original Publication: New York, N.Y. : Masson Publishing USA, c1981-c1993.
    • Subject Terms:
      Eye Movements* ; Saccades*; Cerebellum/*pathology ; Myoclonus/*pathology; Female ; Fever of Unknown Origin/physiopathology ; Humans ; Middle Aged ; Olivary Nucleus/pathology ; Paraneoplastic Syndromes/pathology ; Purkinje Cells/pathology
    • Abstract:
      The neuropathologic findings in an idiopathic case of the opsoclonus/myoclonus syndrome are reported. Although neurologic dysfunction may have been more widespread, structural lesions were limited to the cerebellum and inferior olives. Severe depletion of Purkinje cells with preservation of granular cells was evident throughout the neo- and paleocerebellum; however, groups of Purkinje cells were preserved in the archicerebellum. No abnormalities were evident in the paramedian pontine reticular formation of the caudal pons. Inflammation and evidence of anoxic damage were absent. These changes are very similar to those described in paraneoplastic cerebellar cortical degeneration.
    • Publication Date:
      Date Created: 19861201 Date Completed: 19870210 Latest Revision: 20041117
    • Publication Date:
      20250114
    • Accession Number:
      2947929