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A comprehensive meta-analysis of circulation miRNAs in glioma as potential diagnostic biomarker.
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- Author(s): Ma C;Ma C; Nguyen HPT; Nguyen HPT; Luwor RB; Luwor RB; Stylli SS; Stylli SS; Stylli SS; Gogos A; Gogos A; Gogos A; Paradiso L; Paradiso L; Kaye AH; Kaye AH; Kaye AH; Morokoff AP; Morokoff AP; Morokoff AP
- Source:
PloS one [PLoS One] 2018 Feb 14; Vol. 13 (2), pp. e0189452. Date of Electronic Publication: 2018 Feb 14 (Print Publication: 2018).- Publication Type:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms:
- Abstract: Glioma is the most common malignant intracranial tumour. Recently, several publications have suggested that miRNAs can be used as potential diagnostic biomarkers of glioma. Here we performed a meta-analysis to identify the diagnostic accuracy of differentially expressed circulating miRNAs in gliomas. Using PubMed, Medline and Cochrane databases, we searched for studies which evaluated a single or panel of miRNAs from circulating blood as potential biomarkers of glioma. Sixteen publications involving 23 studies of miRNAs from serum or plasma met our criteria and were included in this meta-analysis. The pooled diagnostic parameters were calculated by random effect models and overall diagnostic performance of altered miRNAs was illustrated by the summary receiver operator characteristic (SROC) curves. The pooled sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) from each study were calculated. The pooled PLR, NLR and Diagnostic Odds Ratio were 6.39 (95% CI, 4.61-8.87), 0.15 (95% CI, 0.11-0.21) and 41.91 (95% CI, 23.15-75.88), respectively. The pooled sensitivity, specificity and area under the curve (AUC) were 0.87 (95% CI, 0.82-0.91), 0.86 (95% CI, 0.82-0.90) and 0.93 (95% CI, 0.91-0.95), respectively. This meta-analysis demonstrated that circulating miRNAs are capable of distinguishing glioma from healthy controls. Circulating miRNAs are promising diagnostic biomarkers for glioma and can potentially be used as a non-invasive early detection.
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N Engl J Med. 2005 Mar 10;352(10 ):987-96. (PMID: 15758009) - Accession Number: 0 (Biomarkers)
0 (MicroRNAs) - Publication Date: Date Created: 20180215 Date Completed: 20180309 Latest Revision: 20181113
- Publication Date: 20240628
- Accession Number: PMC5812551
- Accession Number: 10.1371/journal.pone.0189452
- Accession Number: 29444091
- Source:
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