[Effects of oral contraceptives on fibrinolytic system among Japanese and American women].

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  • Author(s): Ogino M
  • Source:
    Nihon Sanka Fujinka Gakkai zasshi [Nihon Sanka Fujinka Gakkai Zasshi] 1986 Jun; Vol. 38 (6), pp. 817-26.
  • Publication Type:
    Journal Article
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Nippon Sanka Fujinka Gakkai Country of Publication: Japan NLM ID: 7505749 Publication Model: Print Cited Medium: Print ISSN: 0300-9165 (Print) Linking ISSN: 03009165 NLM ISO Abbreviation: Nihon Sanka Fujinka Gakkai Zasshi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo, Nippon Sanka Fujinka Gakkai.
    • Subject Terms:
      Asian People* ; White People*; Contraceptives, Oral/*pharmacology ; Fibrinolysin/*urine ; Fibrinolysis/*drug effects; Adult ; Animals ; Female ; Fibrin Fibrinogen Degradation Products/urine ; Humans ; Japan ; Mestranol/pharmacology ; Norethindrone/pharmacology ; Rabbits ; Rats ; Thrombin/pharmacology ; United States
    • Abstract:
      Neither urinary plasmin-activity nor whole plasmin changed during the menstrual period of healthy women. Among Japanese women, pill-takers' recorded a markedly higher level of plasmin-activity than non-takers. No such trend was observed with whole plasmin and FDP. Among American women, no significant difference between non-users and users concerning the levels of whole plasmin, plasmin activity and FDP was observed. Among Japanese women, a significantly high level of plasmin activity was observed after administering pills for one year. Five out of six rabbits treated with thrombin intramuscularly showed a level of urinary plasmin activity which is five times higher than the control. The number of platelets decreased in two rabbits, the amounts of fibrinogen in one, and prothrombin time in one. Plasmin activity did not change in rabbits treated with 1/20 X and 1 X maximal tolerated dose (MTD) of norethisterone and mestranol, but was significantly increased by 50 X MTD of norethisterone and mestranol. On the other hand, when treated with both norethisterone and mestranol, plasmin activity did not change with 1/20 X but significantly increased with 1 X and 50 X. The activity of plasminogen activator in glomeruli of rats was increased dose-dependently by thrombin. However, norethisterone, mestranol, and norethisterone-mestranol failed to activate production of plasminogen activator. In conclusion, looking at the comparison of the fibrinolytic system of American and Japanese women, the fibrinolytic system in endothelial cells was found to react well to thrombin among Japanese but weakly among Americans. The weak reaction of the fibrinolytic system among Americans is suggested to be a cause of the increase in thrombosis.
    • Contributed Indexing:
      Indexing Agency: PIP Local ID #: 041221. Indexing Agency: POP Local ID #: 00168548.
      Keywords: Americas; Animals, Laboratory*; Asia; Biology; Blood Coagulation Effects*; Cardiovascular Effects; Cerebrovascular Effects; Clinical Research*; Comparative Studies*; Contraception*; Contraceptive Agents; Contraceptive Agents, Female*; Contraceptive Methods--side effects; Developed Countries; Developing Countries; Diseases*; Eastern Asia*; Economic Factors; Family Planning*; Fibrinolysis*; Hematological Effects*; Hemic System; Japan; North America; Northern America*; Oral Contraceptives--side effects*; Physiology; Research And Development*; Research Methodology; Studies; Technology; Thromboembolism; Thrombosis; United States; Vascular Diseases
      Note: TJ: NIPPON SANKA FUJINKA GAKKAI ZASSHI.
      Local Abstract: [PIP] The effects of oral contraceptives (OCs) on the fibrinolytic system among Japanese and American women are discussed. Data are based upon experiments performed on healthy Japanese and American women as well as on New Zealand white rabbits (each weighing 3.0 kg) and Wistar rats (each weighing 200 g). The OCs tested included noresthisterone, mestranol, and noresthisterone plus mestranol. There is more plasmin in the urine of Japanese women using (OCs) (.008+or-.0003 cytoplasmic tubular aggregate (CTA) unit/ml) than those not taking OCs (.0063+or-.0003 CTA unit/ml). However, no such difference was observed between American users and nonusers of OCs. In a comparison of Japanese and American women using OCs; experiments show that the effects on the fibrinolytic system were considerably better among the Japanese women than among the Americans, indicating a decrease in the Japanese women's risk of cerebral thrombosis.
    • Accession Number:
      0 (Contraceptives, Oral)
      0 (Fibrin Fibrinogen Degradation Products)
      B2V233XGE7 (Mestranol)
      EC 3.4.21.5 (Thrombin)
      EC 3.4.21.7 (Fibrinolysin)
      T18F433X4S (Norethindrone)
    • Publication Date:
      Date Created: 19860601 Date Completed: 19860916 Latest Revision: 20221207
    • Publication Date:
      20250114
    • Accession Number:
      2942614