Menu
×
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Decreased global myocardial perfusion at adenosine stress as a potential new biomarker for microvascular disease in systemic sclerosis: a magnetic resonance study.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Gyllenhammar T;Gyllenhammar T; Kanski M; Kanski M; Engblom H; Engblom H; Wuttge DM; Wuttge DM; Carlsson M; Carlsson M; Hesselstrand R; Hesselstrand R; Arheden H; Arheden H
- Source:
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2018 Jan 30; Vol. 18 (1), pp. 16. Date of Electronic Publication: 2018 Jan 30.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE
- Publication Information: Original Publication: London : BioMed Central, [2001-
- Subject Terms: Coronary Circulation* ; Magnetic Resonance Imaging, Cine* ; Microcirculation*; Adenosine/*administration & dosage ; Heart Diseases/*diagnostic imaging ; Myocardial Perfusion Imaging/*methods ; Scleroderma, Systemic/*complications ; Vasodilator Agents/*administration & dosage; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Fibrosis ; Heart Diseases/etiology ; Heart Diseases/physiopathology ; Humans ; Male ; Middle Aged ; Myocardium/pathology ; Predictive Value of Tests ; Scleroderma, Systemic/diagnosis ; Ventricular Remodeling
- Abstract: Background: Patients with systemic sclerosis (SSc) have high cardiovascular mortality even though there is no or little increase in prevalence of epicardial coronary stenosis. First-pass perfusion on cardiovascular magnetic resonance (CMR) have detected perfusion defects indicative of microvascular disease, but the quantitative extent of hypoperfusion is not known. Therefore, we aimed to determine if patients with SSc have lower global myocardial perfusion (MP) at rest or during adenosine stress, compared to healthy controls, quantified with CMR.
Methods: Nineteen SSc patients (17 females, 61 ± 10 years) and 22 controls (10 females, 62 ± 11 years) underwent CMR. Twelve patients had limited cutaneous SSc and 7 patients had diffuse cutaneous SSc. One patient had pulmonary arterial hypertension (PAH). MP was quantified using coronary sinus flow (CSF) measurements at rest and during adenosine stress, divided by left ventricular mass (LVM).
Results: There was no difference in MP at rest between patients and controls (1.1 ± 0.5 vs. 1.1 ± 0.3 ml/min/g, P = 0.85) whereas SSc patients showed statistically significantly lower MP during adenosine stress (3.1 ± 0.9 vs. 4.2 ± 1.3 ml/min/g, P = 0.008). Three out of the 19 SSc patients showed fibrosis in the right ventricle insertion points despite absence of PAH. None had signs of myocardial infarction.
Conclusions: Patients with SSc have decreased MP during adenosine stress compared to healthy controls. Thus hypoperfusion at stress may be a sensitive marker of cardiac disease in SSc patients possibly signifying microvascular myocardial disease. - References: J Rheumatol. 2017 Aug;44(8):1198-1205. (PMID: 28507181)
Eur J Nucl Med Mol Imaging. 2004 Feb;31(2):261-91. (PMID: 15129710)
Rheumatology (Oxford). 2006 Oct;45 Suppl 4:iv14-7. (PMID: 16980717)
Lab Invest. 2017 Jul;97(7):806-818. (PMID: 28346399)
Microvasc Res. 2017 Nov;114:46-51. (PMID: 28619664)
Eur Heart J Cardiovasc Imaging. 2014 Dec;15(12):1350-7. (PMID: 25139907)
Arch Cardiovasc Dis. 2010 Jan;103(1):46-52. (PMID: 20142120)
Ann Rheum Dis. 2003 Sep;62(9):890-3. (PMID: 12922965)
BMC Med Imaging. 2009 Jun 11;9:9. (PMID: 19519892)
Ann Rheum Dis. 2010 Oct;69(10):1809-15. (PMID: 20551155)
Curr Opin Rheumatol. 2008 Nov;20(6):697-702. (PMID: 18946331)
Arthritis Res Ther. 2013 Jan 09;15(1):R8. (PMID: 23302110)
Microvasc Res. 2016 Jul;106:39-43. (PMID: 27003713)
Circulation. 2005 Nov 22;112(21):3337-47. (PMID: 16301360)
Arthritis Rheum. 2008 Jun;58(6):1803-9. (PMID: 18512815)
Rheumatology (Oxford). 2012 Jun;51(6):1017-26. (PMID: 21900368)
Rheumatology (Oxford). 2015 Apr;54(4):647-54. (PMID: 25239881)
Arthritis Rheum. 2011 Jul;63(7):2078-90. (PMID: 21480189)
Ann Rheum Dis. 2008 Jan;67(1):59-63. (PMID: 17519276)
Arthritis Rheum. 1996 Apr;39(4):677-81. (PMID: 8630120)
Ann Rheum Dis. 1998 Nov;57(11):682-6. (PMID: 9924211)
Arthritis Res Ther. 2017 Jul 6;19(1):162. (PMID: 28683836)
Ann Rheum Dis. 2013 Nov;72(11):1747-55. (PMID: 24092682)
Int J Biochem Cell Biol. 2015 Oct;67:86-91. (PMID: 26055516)
Ann Transl Med. 2015 Jan;3(1):8. (PMID: 25705640)
Radiology. 2000 Nov;217(2):487-93. (PMID: 11058650)
Clin Physiol Funct Imaging. 2015 Jan;35(1):49-56. (PMID: 24418159)
Rheumatology (Oxford). 2006 Nov;45(11):1395-8. (PMID: 16606654)
Inflamm Allergy Drug Targets. 2015 ;14 (1):29-36. (PMID: 26374223)
J Cardiovasc Magn Reson. 2010 Oct 08;12:57. (PMID: 20932314)
Ann Rheum Dis. 2005 Sep;64(9):1268-73. (PMID: 15708883)
J Magn Reson Imaging. 2001 May;13(5):722-8. (PMID: 11329193)
Br Heart J. 1968 Jan;30(1):105-9. (PMID: 5637542)
Arthritis Rheum. 1985 Jun;28(6):637-46. (PMID: 4004974)
Am J Med. 1969 Mar;46(3):428-40. (PMID: 5780367)
Eur Heart J Cardiovasc Imaging. 2015 Jan;16(1):74-80. (PMID: 25190071)
Arthritis Rheum. 2000 Nov;43(11):2437-44. (PMID: 11083266)
Circulation. 2000 Jun 13;101(23):2696-702. (PMID: 10851206)
BMC Med Imaging. 2010 Jan 11;10:1. (PMID: 20064248)
J Cardiovasc Magn Reson. 2017 Oct 19;19(1):78. (PMID: 29047385) - Contributed Indexing: Keywords: Cardiovascular magnetic resonance imaging; Coronary sinus flow; Microvascular disease; Scleroderma; Systemic sclerosis
- Accession Number: 0 (Vasodilator Agents)
K72T3FS567 (Adenosine) - Publication Date: Date Created: 20180201 Date Completed: 20180725 Latest Revision: 20181113
- Publication Date: 20221213
- Accession Number: PMC5791343
- Accession Number: 10.1186/s12872-018-0756-x
- Accession Number: 29382301
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.