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Effects of the sodium-glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and Stages 3b-4 chronic kidney disease.
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- Author(s): Dekkers CCJ;Dekkers CCJ; Wheeler DC; Wheeler DC; Sjöström CD; Sjöström CD; Stefansson BV; Stefansson BV; Cain V; Cain V; Heerspink HJL; Heerspink HJL
- Source:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2018 Nov 01; Vol. 33 (11), pp. 2005-2011.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Oxford University Press Country of Publication: England NLM ID: 8706402 Publication Model: Print Cited Medium: Internet ISSN: 1460-2385 (Electronic) Linking ISSN: 09310509 NLM ISO Abbreviation: Nephrol Dial Transplant Subsets: MEDLINE
- Publication Information: Publication: Oxford : Oxford University Press
Original Publication: [Berlin ; New York, NY] : Springer International, [c1986- - Subject Terms: Benzhydryl Compounds/*therapeutic use ; Diabetes Mellitus, Type 2/*drug therapy ; Glucosides/*therapeutic use ; Hypoglycemic Agents/*therapeutic use ; Renal Insufficiency, Chronic/*complications ; Sodium-Glucose Transporter 2 Inhibitors/*therapeutic use; Adult ; Aged ; Albuminuria/chemically induced ; Benzhydryl Compounds/adverse effects ; Blood Pressure/drug effects ; Body Weight/drug effects ; Creatinine/urine ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Female ; Glomerular Filtration Rate/drug effects ; Glucosides/adverse effects ; Glycated Hemoglobin/metabolism ; Humans ; Hypoglycemic Agents/adverse effects ; Male ; Middle Aged ; Randomized Controlled Trials as Topic ; Renal Insufficiency, Chronic/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects
- Abstract: Background: The sodium-glucose co-transporter 2 inhibitor dapagliflozin decreases haemoglobin A1c (HbA1c), body weight, blood pressure (BP) and urinary albumin:creatinine ratio (UACR) in patients with type 2 diabetes. The efficacy and safety of this drug have not been properly defined in patients with type 2 diabetes and Stages 3b-4 chronic kidney disease (CKD).
Methods: In a pooled analysis of 11 phase 3 randomized controlled clinical trials, we determined least square mean changes in HbA1c, body weight, BP, estimated glomerular filtration rate (eGFR) and UACR over 102 weeks in patients with type 2 diabetes and an eGFR between 12 to less than 45 mL/min/1.73 m2 receiving placebo (n = 69) or dapagliflozin 5 or 10 mg (n = 151). Effects on UACR were determined in a subgroup of patients with baseline UACR ≥30 mg/g (n = 136).
Results: Placebo-corrected changes in HbA1c with dapagliflozin 5 and 10 mg were 0.03% [95% confidence interval (CI) -0.3-0.3] and 0.03% (95% CI -0.2-0.3) during the overall 102-week period. Dapagliflozin 5 and 10 mg compared with placebo reduced UACR by - 47.1% (95% CI -64.8 to - 20.6) and -38.4% (95% CI -57.6 to - 10.3), respectively. Additionally, dapagliflozin 5 and 10 mg compared with placebo reduced BP and body weight. eGFR increased with placebo during the first 4 weeks but did not change with dapagliflozin. There were no between-group differences in eGFR at the end of follow-up. Adverse events associated with renal function occurred more frequently in the dapagliflozin 10-mg group. These events were mainly asymptomatic increases in serum creatinine.
Conclusions: Dapagliflozin did not decrease HbA1c in patients with type 2 diabetes and Stages 3b-4 CKD, but decreased UACR, BP and body weight to a clinically meaningful extent. These results support a large outcome trial in this population to confirm long-term safety and efficacy in reducing adverse clinical endpoints. - Comments: Erratum in: Nephrol Dial Transplant. 2018 Jul 1;33(7):1280. (PMID: 29762740)
- References: Diabetes Care. 2017 Nov;40(11):1479-1485. (PMID: 28827404)
Diabetes Obes Metab. 2014 Feb;16(2):159-69. (PMID: 23906445)
J Am Geriatr Soc. 2014 Jul;62(7):1252-62. (PMID: 24890683)
J Am Soc Nephrol. 2013 Feb;24(2):302-8. (PMID: 23362314)
Circulation. 2016 Sep 6;134(10):752-72. (PMID: 27470878)
Diabetes Care. 2010 Oct;33(10):2217-24. (PMID: 20566676)
J Am Soc Nephrol. 2015 Aug;26(8):2055-64. (PMID: 25421558)
Diabetes Care. 2014;37(3):740-50. (PMID: 24144654)
Lancet Diabetes Endocrinol. 2014 May;2(5):369-84. (PMID: 24795251)
Ann Intern Med. 2012 Mar 20;156(6):405-15. (PMID: 22431673)
BMC Res Notes. 2014 Jul 02;7:415. (PMID: 24990184)
Diabetes Obes Metab. 2011 Oct;13(10):928-38. (PMID: 21672123)
Nephrol Dial Transplant. 2015 Aug;30(8):1272-6. (PMID: 25230708)
Diabetes Care. 2012 Jul;35(7):1473-8. (PMID: 22446170)
Nat Rev Nephrol. 2012 Feb 21;8(5):293-300. (PMID: 22349487)
N Engl J Med. 2016 Jul 28;375(4):323-34. (PMID: 27299675)
Kidney Int. 2014 Apr;85(4):962-71. (PMID: 24067431)
Lancet Diabetes Endocrinol. 2017 Aug;5(8):610-621. (PMID: 28666775)
Diabetes Care. 2015 Jul;38(7):1218-27. (PMID: 25852208)
Postgrad Med. 2017 Jan;129(1):159-168. (PMID: 27894216)
Curr Osteoporos Rep. 2016 Dec;14(6):345-350. (PMID: 27709509)
Diabetes Obes Metab. 2014 Oct;16(10):1016-27. (PMID: 24965700)
Lancet. 2010 Jun 26;375(9733):2223-33. (PMID: 20609968)
Med Clin North Am. 1998 Jul;82(4):665-87. (PMID: 9706116)
Diabetes Obes Metab. 2016 Jun;18(6):590-7. (PMID: 26936519)
Int J Clin Pract. 2012 May;66(5):446-56. (PMID: 22413962)
N Engl J Med. 2017 Aug 17;377(7):644-657. (PMID: 28605608) - Accession Number: 0 (Benzhydryl Compounds)
0 (Glucosides)
0 (Glycated Hemoglobin A)
0 (Hypoglycemic Agents)
0 (Sodium-Glucose Transporter 2 Inhibitors)
1ULL0QJ8UC (dapagliflozin)
AYI8EX34EU (Creatinine) - Publication Date: Date Created: 20180126 Date Completed: 20191009 Latest Revision: 20221207
- Publication Date: 20240628
- Accession Number: PMC6212718
- Accession Number: 10.1093/ndt/gfx350
- Accession Number: 29370424
- Source:
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