Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex.

Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE

Original Publication: New York, NY : Oxford University Press, c1991-

Nerve Net/*physiology ; Neurons/*physiology ; Prefrontal Cortex/*cytology ; Synapses/*physiology ; Visual Cortex/*cytology; 8-Bromo Cyclic Adenosine Monophosphate/pharmacology ; Animals ; Cardiovascular Agents/pharmacology ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/ultrastructure ; Dendritic Spines/drug effects ; Dendritic Spines/ultrastructure ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/pharmacology ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/ultrastructure ; Macaca mulatta ; Membrane Potentials/drug effects ; Microscopy, Immunoelectron ; Nerve Net/drug effects ; Neurons/drug effects ; Neurons/ultrastructure ; Photic Stimulation ; Pyrimidines/pharmacology ; Signal Transduction/drug effects ; Synapses/drug effects ; Synapses/ultrastructure

Neurons in primary visual cortex (V1) are more resilient than those in dorsolateral prefrontal cortex (dlPFC) in aging, schizophrenia and Alzheimer's disease. The current study compared glutamate and neuromodulatory actions in macaque V1 to those in dlPFC, and found striking regional differences. V1 neuronal firing to visual stimuli depended on AMPA receptors, with subtle NMDA receptor contributions, while dlPFC depends primarily on NMDA receptors. Neuromodulatory actions also differed between regions. In V1, cAMP signaling increased neuronal firing, and the phosphodiesterase PDE4A was positioned to regulate cAMP effects on glutamate release from axons. HCN channels in V1 were classically located on distal dendrites, and enhanced cell firing. These data contrast with dlPFC, where PDE4A and HCN channels are concentrated in thin spines, and cAMP-HCN signaling gates inputs and weakens firing. These regional differences may explain why V1 neurons are more resilient than dlPFC neurons to the challenges of age and disease.

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DP1 AG047744 United States AG NIA NIH HHS; R01 EY025103 United States EY NEI NIH HHS

0 (Cardiovascular Agents)
0 (Excitatory Amino Acid Antagonists)
0 (Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels)
0 (Pyrimidines)
133059-99-1 (ICI D2788)
23583-48-4 (8-Bromo Cyclic Adenosine Monophosphate)
EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4)
EC 3.1.4.17 (PDE4A protein, human)

Date Created: 20180120 Date Completed: 20190626 Latest Revision: 20191008

20231215

PMC6041807

10.1093/cercor/bhx357

29351585