Effects of experimental pain induction on alcohol urge, intention to consume alcohol, and alcohol demand.

Publisher: American Psychological Association Country of Publication: United States NLM ID: 9419066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-2293 (Electronic) Linking ISSN: 10641297 NLM ISO Abbreviation: Exp Clin Psychopharmacol Subsets: MEDLINE

Original Publication: Washington, DC : American Psychological Association, c1993-

Craving* ; Ethanol*/administration & dosage ; Ethanol*/pharmacology ; Intention* ; Reinforcement, Psychology*; Alcohol Drinking/*psychology ; Pain/*psychology; Adolescent ; Adult ; Affect ; Case-Control Studies ; Female ; Humans ; Male ; Young Adult

Research suggests one determinant of alcohol consumption may be physical pain, but there is no empirical evidence that pain has a causal effect on drinking. Therefore, the primary aim of this study was to test experimental pain as a determinant of several alcohol consumption proxies: self-reported urge to drink, intention to consume alcohol, and alcohol demand. This study also was designed to test negative affect as a mediator of the effects of pain on alcohol use proxies. We hypothesized that participants randomized to experimental pain induction (vs. no pain) would report greater urge, intention, and alcohol demand, and that these effects would be mediated by increased negative affect. Participants were healthy undergraduates who were moderate-heavy drinkers (N = 61). Experimental pain was induced using a novel capsaicin-heat model intended to approximate key features of clinical pain. Results indicated that participants in the pain condition subsequently endorsed greater urge and intention to drink. Furthermore, these effects were mediated by pain-induced negative affect. We observed no effect of pain on alcohol demand. This is the first study to demonstrate a causal effect of acute pain on urge and intention to drink. Given the close association between alcohol consumption, urge and intention to drink, these findings suggest that pain may influence alcohol consumption, which can have implications for individuals with co-occurring pain and alcohol use disorder (AUD). Specifically, individuals with co-occurring pain and AUD may drink to alleviate pain-related negative affect. Therefore, improving pain-coping skills may enhance pain-management abilities, subsequently reducing coping-motivated drinking. (PsycINFO Database Record
((c) 2018 APA, all rights reserved).)

J Health Psychol. 2011 May;16(4):688-98. (PMID: 21421643)
Behav Res Methods. 2008 Aug;40(3):879-91. (PMID: 18697684)
Pain. 2015 Mar;156(3):405-414. (PMID: 25687540)
Pain Rep. 2017 Apr 11;2(3):e596. (PMID: 29392212)
Addiction. 2007 May;102(5):752-60. (PMID: 17506152)
Arch Intern Med. 1998 Sep 14;158(16):1789-95. (PMID: 9738608)
Q J Stud Alcohol. 1972 Mar;33(1):33-64. (PMID: 4551021)
Exp Clin Psychopharmacol. 2009 Dec;17(6):396-404. (PMID: 19968404)
Drug Alcohol Depend. 2016 Jun 01;163:216-21. (PMID: 27161860)
Exp Brain Res. 2009 Jun;196(1):173-8. (PMID: 19404625)
Addiction. 2015 Aug;110(8):1262-71. (PMID: 25919978)
J Adv Nurs. 2014 Jun;70(6):1391-403. (PMID: 24224703)
Br J Clin Pharmacol. 2009 Aug;68(2):149-68. (PMID: 19694733)
J Pain Res. 2014 Jul 07;7:389-403. (PMID: 25045282)
Aggress Behav. 2010 Nov-Dec;36(6):405-13. (PMID: 20623578)
Pain. 2002 Sep;99(1-2):207-16. (PMID: 12237198)
J Consult Clin Psychol. 2015 Dec;83(6):1033-43. (PMID: 26167945)
Clin Psychol Rev. 2015 Apr;37:57-71. (PMID: 25766100)
J Neurosci. 2015 Sep 02;35(35):12217-31. (PMID: 26338332)
Exp Econ. 2017;20(4):878-893. (PMID: 29151807)
Psychol Bull. 1999 May;125(3):356-66. (PMID: 10349356)
J Pain. 2003 Nov;4(9):520-9. (PMID: 14636820)
Psychol Health Med. 2009 Aug;14(4):487-501. (PMID: 19697258)
Clin Neurophysiol. 2012 Jul;123(7):1429-36. (PMID: 22188747)
J Pers Soc Psychol. 1988 Jun;54(6):1063-70. (PMID: 3397865)
Value Health. 2011 Jul-Aug;14(5 Suppl 1):S122-5. (PMID: 21839883)
Addiction. 2016 Aug;111(8):1385-93. (PMID: 26879036)
Front Psychiatry. 2012 Jul 02;3:65. (PMID: 22783209)
J Pain. 2006 Mar;7(3):211-7. (PMID: 16516827)
J Abnorm Psychol. 2008 May;117(2):467-72. (PMID: 18489224)
Pain. 2015 Apr;156(4):569-576. (PMID: 25785523)
Pain. 2006 Jun;122(3):295-305. (PMID: 16540248)
Pain. 2009 Jan;141(1-2):114-8. (PMID: 19081190)
Somatosens Mot Res. 1992;9(4):265-77. (PMID: 1492527)
Clin J Pain. 2013 Aug;29(8):689-95. (PMID: 23835765)
Alcohol Res Health. 1999;23(3):225-32. (PMID: 10890818)
Alcohol Clin Exp Res. 2006 Jan;30(1):57-69. (PMID: 16433732)
Exp Clin Psychopharmacol. 1999 Nov;7(4):412-26. (PMID: 10609976)
Brain. 2001 Sep;124(Pt 9):1754-64. (PMID: 11522578)
J Stud Alcohol. 1993 Nov;54(6):710-21. (PMID: 8271807)
JAMA Psychiatry. 2015 May;72(5):430-7. (PMID: 25760804)
Addiction. 2005 Jun;100(6):777-86. (PMID: 15918808)
J Stud Alcohol. 2003 Jan;64(1):120-6. (PMID: 12608492)
J Pain. 2010 Nov;11(11):1230-9. (PMID: 20797916)
Addiction. 2001 Jan;96(1):33-46. (PMID: 11177518)
J Abnorm Psychol. 1973 Jun;81(3):233-41. (PMID: 4710045)
Addiction. 2008 Dec;103(12):1996-2005. (PMID: 18855809)
Drug Alcohol Depend. 2004 Jan 7;73(1):23-31. (PMID: 14687956)
Drug Alcohol Depend. 2015 Jan 1;146:39-44. (PMID: 25468819)
Addiction. 2016 May;111(5):806-16. (PMID: 26616514)
J Abnorm Psychol. 2010 Aug;119(3):524-33. (PMID: 20677841)
Psychol Rev. 2004 Jan;111(1):33-51. (PMID: 14756584)
Pain Med. 2016 Nov;17(11):2067-2075. (PMID: 26995798)
J Pain. 2011 Jan;12(1):133-40. (PMID: 20692209)
Neurosci Biobehav Rev. 2009 Mar;33(3):205-12. (PMID: 18761036)
Pain. 2008 Oct 15;139(2):416-430. (PMID: 18614290)
J Consult Clin Psychol. 2015 Dec;83(6):1044-57. (PMID: 26098375)
Alcohol Clin Exp Res. 2012 Apr;36(4):716-24. (PMID: 22017303)
Psychol Assess. 2012 Dec;24(4):954-63. (PMID: 22612646)
Addict Behav. 2013 Feb;38(2):1572-1584. (PMID: 23142210)
Psychopharmacology (Berl). 2009 Mar;203(1):33-40. (PMID: 18925387)
J Addict Res Ther. 2013 May 24;4:151. (PMID: 24511431)
J Pain Symptom Manage. 2011 May;41(5):848-58. (PMID: 21256706)
Drug Alcohol Depend. 2009 Jul 1;103(1-2):84-91. (PMID: 19423243)
Drug Alcohol Depend. 2014 Nov 1;144:87-92. (PMID: 25220898)
J Abnorm Psychol. 1982 Oct;91(5):350-67. (PMID: 7142573)
Pain. 2011 Oct;152(10):2399-2404. (PMID: 21856077)
Pain. 2007 Jun;129(3):332-342. (PMID: 17350169)
J Pain. 2009 Sep;10(9):944-52. (PMID: 19712901)
Am J Psychiatry. 1985 Nov;142(11):1259-64. (PMID: 3904487)
Psychol Addict Behav. 2014 Mar;28(1):282-7. (PMID: 23915370)
J Pain. 2003 Apr;4(3):122-8. (PMID: 14622709)
Science. 1999 Jun 18;284(5422):1979-81. (PMID: 10373114)
Mil Med. 2016 Jul;181(7):663-71. (PMID: 27391620)
J Pain. 2017 May;18(5):499-510. (PMID: 27919773)
Fam Pract. 2008 Dec;25(6):445-9. (PMID: 18826990)
Drug Alcohol Depend. 2016 Jul 01;164:166-171. (PMID: 27234659)
J Res Med Sci. 2012 Jun;17(6):587-95. (PMID: 23626642)
Addiction. 2010 Sep;105(9):1599-607. (PMID: 20626376)
Clin J Pain. 2013 Jan;29(1):2-8. (PMID: 23211602)
J Pain. 2015 Aug;16(8):769-80. (PMID: 26028573)
Pain. 1994 Feb;56(2):217-226. (PMID: 8008411)
J Pain. 2011 Nov;12(11):1190-6. (PMID: 21865092)

K05 AA016928 United States AA NIAAA NIH HHS; R01 AA024844 United States AA NIAAA NIH HHS; International Syracuse University; Department of Psychology

3K9958V90M (Ethanol)

Date Created: 20180112 Date Completed: 20181109 Latest Revision: 20240313

20240313

PMC5794517

10.1037/pha0000170

29323505