Metabolism and pharmacokinetics of resveratrol and pterostilbene.

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  • Author(s): Wang P;Wang P; Sang S; Sang S
  • Source:
    BioFactors (Oxford, England) [Biofactors] 2018 Jan; Vol. 44 (1), pp. 16-25. Date of Electronic Publication: 2018 Jan 08.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8081 (Electronic) Linking ISSN: 09516433 NLM ISO Abbreviation: Biofactors Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Ios Press
      Original Publication: Oxford ; Washington, DC : Published for the International Union of Biochemistry by IRL Press, [c1988-
    • Subject Terms:
      Glucuronosyltransferase/*metabolism ; Stilbenes/*pharmacokinetics; Administration, Oral ; Animals ; Biological Availability ; Biotransformation ; Clinical Trials as Topic ; Half-Life ; Humans ; Injections, Intravenous ; Mice ; Rats ; Resveratrol ; Solubility ; Stilbenes/blood
    • Abstract:
      Beneficial properties of resveratrol and pterostilbene, a dimethyl ether analog of resveratrol, have attracted increasing interest in recent years. Resveratrol and pterostilbene exhibit many pharmacological similarities and both of them are generally considered to be safe for human consumption. Beyond the structural and general bioactivity similarities between them, large amounts of data are now available to reveal the metabolic fate and pharmacological differences between them. Pterostilbene was found to be more metabolically stable and usually exhibited stronger pharmacological activities than that of resveratrol. As a contribution to clarify and compare aspects like metabolic stability and pharmacokinetics of resveratrol and pterostilbene, as well as explain the pharmacological similarities and differences between them, this review presents and compares recent data on the metabolism and pharmacokinetics of resveratrol and pterostilbene. © 2018 BioFactors, 44(1):16-25, 2018.
      (© 2018 International Union of Biochemistry and Molecular Biology.)
    • Contributed Indexing:
      Keywords: metabolism; pharmacokinetics; pharmacological activities; pterostilbene; resveratrol
    • Accession Number:
      0 (Stilbenes)
      26R60S6A5I (pterostilbene)
      EC 2.4.1.- (UGT1A1 enzyme)
      EC 2.4.1.17 (Glucuronosyltransferase)
      Q369O8926L (Resveratrol)
    • Publication Date:
      Date Created: 20180110 Date Completed: 20180808 Latest Revision: 20181202
    • Publication Date:
      20231215
    • Accession Number:
      10.1002/biof.1410
    • Accession Number:
      29315886