The Role of Aquaporins in Ocular Lens Homeostasis.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Homeostasis*; Aquaporins/*physiology ; Eye Proteins/*metabolism ; Lens, Crystalline/*metabolism; Animals ; Aquaporins/genetics ; Aquaporins/metabolism ; Biological Transport, Active ; Humans ; Permeability ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Isoforms/physiology ; Water/metabolism ; Water/physiology
    • Abstract:
      Abstract : Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens homeostasis, contribute to the establishment and maintenance of the overall optical properties of the lens over many decades of life. Three aquaporins, AQP0, AQP1 and AQP5, each with distinctly different functional properties, are abundantly and differentially expressed in the different regions of the ocular lens. Furthermore, the diversity of AQP functionality is increased in the absence of protein turnover by age-related modifications to lens AQPs that are proposed to alter AQP function in the different regions of the lens. These regional differences in AQP functionality are proposed to contribute to the generation and directionality of the lens internal microcirculation; a system of circulating ionic and fluid fluxes that delivers nutrients to and removes wastes from the lens faster than could be achieved by passive diffusion alone. In this review, we present how regional differences in lens AQP isoforms potentially contribute to this microcirculation system by highlighting current areas of investigation and emphasizing areas where future work is required.
      Competing Interests: The authors declare no conflict of interest.
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    • Grant Information:
      R01 EY013462 United States EY NEI NIH HHS; R25 GM062459 United States GM NIGMS NIH HHS
    • Contributed Indexing:
      Keywords: hydrostatic pressure; microcirculation; post-translational modification; regulation
    • Accession Number:
      0 (Aquaporins)
      0 (Eye Proteins)
      0 (Protein Isoforms)
      059QF0KO0R (Water)
    • Publication Date:
      Date Created: 20171213 Date Completed: 20180724 Latest Revision: 20240327
    • Publication Date:
      20240327
    • Accession Number:
      PMC5751294
    • Accession Number:
      10.3390/ijms18122693
    • Accession Number:
      29231874