Adherence to inhaled therapies of COPD patients from seven Latin American countries: The LASSYC study.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Patient Compliance*; Bronchodilator Agents/*administration & dosage ; Pulmonary Disease, Chronic Obstructive/*drug therapy; Administration, Inhalation ; Aged ; Bronchodilator Agents/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Latin America ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/physiopathology
    • Abstract:
      Background: This study assessed the adherence profiles to inhaled therapies and the agreement between two patient self-report adherence methods in stable COPD lpatients from seven Latin American countries.
      Methods: This observational, cross-sectional, multinational, multicenter study involved 795 COPD patients (post-bronchodilator forced expiratory volume in 1 second/forced vital capacity [FEV1/FVC] <0.70). Adherence to inhaled therapy was assessed using the specific Test of Adherence to Inhalers (10-item TAI) and the generic 8-item Morisky Medication Adherence Scale (MMAS-8) questionnaires. The percentage agreement and the kappa index were used to compare findings.
      Results: 59.6% of patients were male (69.5±8.7 years); post-bronchodilator FEV1 percent predicted was 50.0±18.6%. Mean values for 10-item TAI and MMAS-8 questionnaires were 47.4±4.9 and 6.8±1.6, respectively. Based on the TAI questionnaire, 54.1% of patients had good, 26.5% intermediate, and 19.4% poor adherence. Using the MMAS-8 questionnaire, 51% had high, 29.1% medium, and 19.9% low adherence. According to both questionnaires, patients with poor adherence had lower smoking history, schooling but higher COPD Assessment Test score, exacerbations in the past-year and post-bronchodilator FEV1. The agreement between 10-item TAI and MMAS-8 questionnaires was moderate (Kappa index: 0.42; agreement: 64.7%).
      Conclusion: Suboptimal adherence to medication was frequent in COPD patients from Latin America. Low adherence was associated with worse health status impairment and more exacerbations. There was inadequate agreement between the two questionnaires. Greater effort should be made to improve COPD patients' adherence to treatment, and assessment of adherence with more specific instruments, such as the TAI questionnaire, would be more convenient in these patients.
      Clinical Trial Registration: NCT02789540.
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    • Molecular Sequence:
      ClinicalTrials.gov NCT02789540
    • Accession Number:
      0 (Bronchodilator Agents)
    • Publication Date:
      Date Created: 20171116 Date Completed: 20171211 Latest Revision: 20220409
    • Publication Date:
      20221213
    • Accession Number:
      PMC5687703
    • Accession Number:
      10.1371/journal.pone.0186777
    • Accession Number:
      29140978