QSPR in forensic analysis - The prediction of retention time of pesticide residues based on the Monte Carlo method.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Oxford : Pergamon Press
    • Subject Terms:
      Chromatography, Gas* ; Forensic Sciences* ; Monte Carlo Method*; Pesticide Residues/*chemistry ; Pesticide Residues/*pharmacology; Models, Statistical ; Quantitative Structure-Activity Relationship
    • Abstract:
      A method for the prediction of retention indices of pesticides using the Monte Carlo method and with optimal molecular descriptors based on local graph invariants and the SMILES notation of studied compounds has been presented. Quite satisfactory results were obtained with the proposed method, since a robust model with good statistical quality was developed. The predictive potential of the applied approach was tested and the robustness of the model was proven with different methods. The best calculated QSPR model had following statistical parameters: r 2 = 0.9182 for the training set and r 2 = 0.8939 for the test set. Structural indicators defined as molecular fragments responsible for the increases and decreases of gas chromatographic retention indices activity were calculated.
      (Copyright © 2017 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Gas chromatographic retention indices; Molecular graph; Pesticides; QSPR; SMILES
    • Accession Number:
      0 (Pesticide Residues)
    • Publication Date:
      Date Created: 20171116 Date Completed: 20180921 Latest Revision: 20180921
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.talanta.2017.09.064
    • Accession Number:
      29136877