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Biomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort.
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- Author(s): Ferreira I;Ferreira I; Hovind P; Hovind P; Hovind P; Schalkwijk CG; Schalkwijk CG; Schalkwijk CG; Parving HH; Parving HH; Stehouwer CDA; Stehouwer CDA; Stehouwer CDA; Rossing P; Rossing P; Rossing P; Rossing P
- Source:
Diabetologia [Diabetologia] 2018 Jan; Vol. 61 (1), pp. 231-241. Date of Electronic Publication: 2017 Nov 03.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
- Publication Information: Original Publication: Berlin Springer Verlag
- Subject Terms:
- Abstract: Aims/hypothesis: Vascular inflammation and endothelial dysfunction are thought to contribute to arterial stiffening and hypertension. This study aims to test this hypothesis with longitudinal data in the context of type 1 diabetes.
Methods: We investigated, in an inception cohort of 277 individuals with type 1 diabetes, the course, tracking and temporal inter-relationships of BP, specifically pulse pressure (a marker of arterial stiffening) and hypertension, and the following biomarkers of systemic and vascular inflammation/endothelial dysfunction: C-reactive protein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin). These biomarkers and other risk factors were measured at baseline and repeatedly up to 20 years after the onset of type 1 diabetes. Data were analysed with generalised estimating equations including adjustments for age, sex, smoking status, BMI, HbA1c , serum creatinine, total cholesterol, urinary AER, insulin treatment dose and mean arterial pressure.
Results: Increases were noted in all biomarkers except sE-selectin, which decreased over time. Levels differed from baseline at 2-4 years and preceded the increase in pulse pressure, which occurred at 8-10 years after the onset of type 1 diabetes. Higher levels of sICAM-1 and sVCAM-1, but not CRP or sE-selectin, at baseline and throughout the 20 year follow-up, were significantly associated with higher (changes in) pulse pressure at subsequent time points. Higher levels of sVCAM-1 at baseline and during follow-up were also significantly associated with the prevalence (OR 3.60 [95% CI 1.36, 9.53] and OR 2.28 [1.03, 5.25], respectively) and incidence (OR 2.89 [1.08, 7.75] and OR 3.06 [1.01, 9.26], respectively) of hypertension. We also investigated the longitudinal associations between BP or hypertension as determinants of subsequent (changes in) levels of CRP, sICAM-1, sVCAM-1 and sE-selectin, but did not find evidence to support a reverse causality hypothesis.
Conclusions/interpretation: These findings support the involvement of vascular endothelial dysfunction and inflammation in the development of premature arterial stiffening and hypertension in type 1 diabetes. - References: J Hypertens. 2004 Apr;22(4):705-11. (PMID: 15126911)
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Curr Vasc Pharmacol. 2010 Jul;8(4):509-16. (PMID: 19538178) - Contributed Indexing: Keywords: Arterial stiffness; CRP; Endothelial dysfunction; Hypertension; Inflammation; Longitudinal study; Pulse pressure; Type 1 diabetes; sE-selectin; sICAM-1; sVCAM-1
- Accession Number: 0 (Biomarkers)
0 (E-Selectin)
126547-89-5 (Intercellular Adhesion Molecule-1)
9007-41-4 (C-Reactive Protein) - Publication Date: Date Created: 20171105 Date Completed: 20180717 Latest Revision: 20190418
- Publication Date: 20240628
- Accession Number: PMC6448953
- Accession Number: 10.1007/s00125-017-4470-5
- Accession Number: 29101422
- Source:
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