Poor perinatal growth impairs baboon aortic windkessel function.

Publisher: Cambridge University Press Country of Publication: England NLM ID: 101517692 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1752 (Electronic) Linking ISSN: 20401744 NLM ISO Abbreviation: J Dev Orig Health Dis Subsets: MEDLINE

Original Publication: Cambridge : Cambridge University Press, 2010-

Aorta/*diagnostic imaging ; Blood Pressure/*physiology ; Fetal Growth Retardation/*diagnostic imaging; Animals ; Aorta/physiopathology ; Female ; Fetal Growth Retardation/physiopathology ; Male ; Papio ; Pregnancy

The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.

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K25 DK089012 United States DK NIDDK NIH HHS; P01 HD021350 United States HD NICHD NIH HHS; P51 OD011133 United States OD NIH HHS; R24 OD011183 United States OD NIH HHS; U19 AG057758 United States AG NIA NIH HHS; R25 EB016631 United States EB NIBIB NIH HHS

Keywords: aorta; baboons; developmental programing; intrauterine growth restriction; maternal nutrient restriction

Date Created: 20171012 Date Completed: 20190524 Latest Revision: 20230917

20240829

PMC5922776

10.1017/S2040174417000770

29017630