Vasopressin modulates the activity of nicotinic cholinergic mechanisms during memory retrieval in mice.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 7905471 Publication Model: Print Cited Medium: Print ISSN: 0163-1047 (Print) Linking ISSN: 01631047 NLM ISO Abbreviation: Behav Neural Biol Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York. London, Academic Press.
    • Subject Terms:
      Cholinergic Fibers/*physiology ; Memory/*drug effects ; Receptors, Nicotinic/*physiology ; Vasopressins/*physiology; Animals ; Arginine Vasopressin/analogs & derivatives ; Arginine Vasopressin/pharmacology ; Atropine/pharmacology ; Cholinergic Fibers/drug effects ; Hexamethonium ; Hexamethonium Compounds/pharmacology ; Lypressin/pharmacology ; Male ; Mecamylamine/pharmacology ; Memory/physiology ; Mice ; Receptors, Muscarinic/drug effects ; Receptors, Muscarinic/physiology ; Receptors, Nicotinic/drug effects ; Vasopressins/pharmacology
    • Abstract:
      Lysine vasopressin (0.03 micrograms/kg, sc) enhanced retention test performance on a one-trial step-through inhibitory avoidance task when injected into male Swiss mice 20 min before the retention test. Tests were done 48 h following training. A low dose of the vasopressin antagonist AAVP (0.01 microgram/kg, sc, 20 min prior to testing) did not significantly affect retention test performance, whereas a higher dose (0.03 microgram/kg, sc) impaired it. Neither lysine vasopressin nor AAVP when given prior to testing modified latencies to step-through of mice that had not received a footshock during training. The simultaneous administration of AAVP (0.01 microgram/kg, sc) prevented the enhancement of retention test performance induced by lysine vasopressin. The influence of lysine vasopressin on retention test performance was antagonized by the simultaneous administration of mecamylamine (5 mg/kg, sc) but not by hexamethonium (5 mg/kg, sc), atropine (0.5 mg/kg, sc), or methylatropine (0.5 mg/kg, sc). A modulatory role of vasopressin on the activity of central cholinergic nicotinic mechanisms which probably operate at the time of testing is suggested.
    • Accession Number:
      0 (Hexamethonium Compounds)
      0 (Receptors, Muscarinic)
      0 (Receptors, Nicotinic)
      11000-17-2 (Vasopressins)
      113-79-1 (Arginine Vasopressin)
      3C9PSP36Z2 (Hexamethonium)
      50-57-7 (Lypressin)
      6EE945D3OK (Mecamylamine)
      73168-24-8 (vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-)
      7C0697DR9I (Atropine)
    • Publication Date:
      Date Created: 19880701 Date Completed: 19880901 Latest Revision: 20190919
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/s0163-1047(88)90816-3
    • Accession Number:
      2900001