Rare sugars, d-allulose, d-tagatose and d-sorbose, differently modulate lipid metabolism in rats.

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  • Additional Information
    • Source:
      Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE
    • Publication Information:
      Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
      Original Publication: London, Society of Chemical Industry.
    • Subject Terms:
      Lipid Metabolism*; Fructose/*metabolism ; Hexoses/*metabolism ; Sorbose/*metabolism; Adipose Tissue/metabolism ; Animals ; Liver/metabolism ; Male ; Rats ; Rats, Sprague-Dawley
    • Abstract:
      Background: Rare sugars including d-allulose, d-tagatose, and d-sorbose are present in limited quantities in nature; some of these rare sugars are now commercially produced using microbial enzymes. Apart from the anti-obesity and anti-hyperglycaemic activities of d-allulose, effects of these sugars on lipid metabolism have not been investigated. Therefore, we aimed to determine if and how d-tagatose and d-sorbose modulate lipid metabolism in rats. After feeding these rare sugars to rats, parameters on lipid metabolism were determined.
      Results: No diet-related effects were observed on body weight and food intake. Hepatic lipogenic enzyme activity was lowered by d-allulose and d-sorbose but increased by d-tagatose. Faecal fatty acid excretion was non-significantly decreased by d-allulose, but significantly increased by d-sorbose without affecting faecal steroid excretion. A trend toward reduced adipose tissue weight was observed in groups fed rare sugars. Serum adiponectin levels were decreased by d-sorbose relative to the control. Gene expression of cholesterol metabolism-related liver proteins tended to be down-regulated by d-allulose and d-sorbose but not by d-tagatose. In the small intestine, SR-B1 mRNA expression was suppressed by d-sorbose.
      Conclusion: Lipid metabolism in rats varies with rare sugars. Application of rare sugars to functional foods for healthy body weight maintenance requires further studies. © 2017 Society of Chemical Industry.
      (© 2017 Society of Chemical Industry.)
    • Contributed Indexing:
      Keywords: d-allulose; d-psicose; d-sorbose; d-tagatose; lipogenesis
    • Accession Number:
      0 (Hexoses)
      23140-52-5 (psicose)
      30237-26-4 (Fructose)
      NV2001607Y (Sorbose)
      T7A20Y888Y (tagatose)
    • Publication Date:
      Date Created: 20170924 Date Completed: 20180322 Latest Revision: 20180322
    • Publication Date:
      20221213
    • Accession Number:
      10.1002/jsfa.8687
    • Accession Number:
      28940418