Tick-host-pathogen systems immunobiology: an interactive trio.

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  • Author(s): Wikel SK;Wikel SK
  • Source:
    Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2018 Jan 01; Vol. 23 (2), pp. 265-283. Date of Electronic Publication: 2018 Jan 01.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: IMR Press Country of Publication: Singapore NLM ID: 101612996 Publication Model: Electronic Cited Medium: Internet ISSN: 2768-6698 (Electronic) Linking ISSN: 27686698 NLM ISO Abbreviation: Front Biosci (Landmark Ed) Subsets: MEDLINE
    • Publication Information:
      Publication: 2022- : Singapore : IMR Press
      Original Publication: Searington, NY : Frontiers in Bioscience
    • Subject Terms:
      Saliva/*metabolism ; Salivary Glands/*metabolism ; Tick-Borne Diseases/*parasitology ; Ticks/*physiology; Animals ; Arthropod Proteins/genetics ; Arthropod Proteins/metabolism ; Gene Expression Profiling/methods ; Host-Pathogen Interactions ; Humans ; Proteomics/methods ; Tick-Borne Diseases/microbiology ; Tick-Borne Diseases/virology ; Ticks/genetics ; Ticks/metabolism
    • Abstract:
      Significant new insights are being made into tick modulation of host immune defenses and the implications of those host defense changes on tick-borne pathogen transmission and establishment of infection. Understanding tick saliva complexity increased with construction and analyses of salivary gland cDNA libraries. High throughput next generation sequencing and advances in proteomics are revealing greater complexity of saliva, nature of gene families and differential gene expression patterns not previously attainable. Combined use of genome arrays and histopathology are defining cutaneous gene expression during the course of infestation with pathogen-free ticks and during infestations with ticks experimentally infected with a tick-borne pathogen. Large data sets are being generated that are of value to researchers. A major challenge remains in linking saliva molecules with specific functions. Systems biology technologies provide the tools for analyses of complex tick-host-pathogen interactions that are the underpinnings for development of novel control strategies for ticks and tick-borne diseases of medical and veterinary public health importance.
    • Accession Number:
      0 (Arthropod Proteins)
    • Publication Date:
      Date Created: 20170921 Date Completed: 20180529 Latest Revision: 20220223
    • Publication Date:
      20231215
    • Accession Number:
      10.2741/4590
    • Accession Number:
      28930546