Menu
×
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Validation of the revised IPSS at transplant in patients with myelodysplastic syndrome/transformed acute myelogenous leukemia receiving allogeneic stem cell transplantation: a retrospective analysis of the EBMT chronic malignancies working party.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Scheid C;Scheid C; de Wreede L; de Wreede L; de Wreede L; van Biezen A; van Biezen A; Koenecke C; Koenecke C; Göhring G; Göhring G; Volin L; Volin L; Maertens J; Maertens J; Finke J; Finke J; Passweg J; Passweg J; Beelen D; Beelen D; Cornelissen JJ; Cornelissen JJ; Itälä-Remes M; Itälä-Remes M; Chevallier P; Chevallier P; Russell N; Russell N; Petersen E; Petersen E; Milpied N; Milpied N; Richard Espiga C; Richard Espiga C; Peniket A; Peniket A; Sierra J; Sierra J; Mufti G; Mufti G; Crawley C; Crawley C; Veelken JH; Veelken JH; Ljungman P; Ljungman P; Cahn JY; Cahn JY; Alessandrino EP; Alessandrino EP; de Witte T; de Witte T; Robin M; Robin M; Kröger N; Kröger N
- Source:
Bone marrow transplantation [Bone Marrow Transplant] 2017 Nov; Vol. 52 (11), pp. 1519-1525. Date of Electronic Publication: 2017 Sep 11.- Publication Type:
Journal Article; Validation Study- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8702459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5365 (Electronic) Linking ISSN: 02683369 NLM ISO Abbreviation: Bone Marrow Transplant Subsets: MEDLINE
- Publication Information: Publication: <2003->: London : Nature Publishing Group
Original Publication: Basingstoke, Hampshire : Scientific & Medical Division, Macmillan Press, c1986- - Subject Terms: Prognosis*; Hematopoietic Stem Cell Transplantation/*methods ; Leukemia, Myeloid, Acute/*diagnosis ; Myelodysplastic Syndromes/*diagnosis; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Databases, Factual ; Disease-Free Survival ; Female ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy ; Male ; Middle Aged ; Myelodysplastic Syndromes/mortality ; Myelodysplastic Syndromes/therapy ; Retrospective Studies ; Risk Factors ; Survival Rate ; Transplantation, Homologous ; Young Adult
- Abstract: The International Prognostic Scoring System has been revised (IPSS-R) to predict prognosis of patients with myelodysplastic syndromes at diagnosis. To validate the use of the IPSS-R assessed before transplant rather than at diagnosis we performed a retrospective analysis of the EBMT database. A total of 579 patients had sufficient information available to calculate IPSS-R at transplant. Median overall survival (OS) from transplant was significantly different according to IPSS-R: very low 23.6 months, low 55.0 months, intermediate 19.7 months, high 13.5 months, very high 7.8 months (P<0.001). In a multivariate Cox model the following parameters were significant risk factors for OS: IPSS-R, graft source, age and prior treatment. Median relapse free survival also showed significant differences according to IPSS-R: very low: 23.6 months, low: 24.8 months, intermediate 10.6 months, high 7.9 months, very high 5.5 months (P<0.001). Multivariate risk factors for relapse-free survival (RFS) were: IPSS-R, reduced intensity conditioning, graft source and prior treatment. A trend for an increased relapse incidence was noted for very high risk IPSS-R. We conclude that the IPSS-R at transplant is a useful prognostic score for predicting OS and RFS after transplantation, capturing both disease evolution and response to prior treatment before transplant.
- References: Bone Marrow Transplant. 2010 Mar;45(3):450-7. (PMID: 19668236)
Blood. 2014 Apr 10;123(15):2333-42. (PMID: 24558201)
J Clin Oncol. 2016 Jun 1;34(16):1864-71. (PMID: 27044940)
Leukemia. 1998 Sep;12 Suppl 1:S25-9. (PMID: 9777891)
Acta Med Port. 2006 Sep-Oct;19(5):343-7. (PMID: 17376319)
Biol Blood Marrow Transplant. 2009 Feb;15(2):137-72. (PMID: 19167676)
Bone Marrow Transplant. 2017 Apr;52(4):522-531. (PMID: 27892952)
J Clin Oncol. 2012 Mar 10;30(8):820-9. (PMID: 22331955)
Blood. 2012 Aug 16;120(7):1398-408. (PMID: 22767498)
Haematologica. 2015 Mar;100(3):400-8. (PMID: 25552702)
Blood. 2012 Sep 20;120(12):2454-65. (PMID: 22740453)
J Clin Oncol. 2016 Sep 6;:null. (PMID: 27601546)
Transplantation. 2015 Aug;99(8):1672-80. (PMID: 25769079)
Blood. 2008 Aug 1;112(3):895-902. (PMID: 18497321) - Publication Date: Date Created: 20170912 Date Completed: 20180625 Latest Revision: 20191210
- Publication Date: 20221213
- Accession Number: PMC5671928
- Accession Number: 10.1038/bmt.2017.171
- Accession Number: 28892084
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.