A Luminescent 3d-4f-4d MOF Nanoprobe as a Diagnosis Platform for Human Occupational Exposure to Vinyl Chloride Carcinogen.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-510X (Electronic) Linking ISSN: 00201669 NLM ISO Abbreviation: Inorg Chem Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Easton, Pa.] American Chemical Society.
    • Subject Terms:
      Carcinogens/*analysis ; Coordination Complexes/*chemistry ; Luminescent Agents/*chemistry ; Nanostructures/*chemistry ; Occupational Exposure/*analysis ; Vinyl Chloride/*analysis; Biomarkers, Tumor/urine ; Coordination Complexes/chemical synthesis ; Humans ; Luminescent Agents/chemical synthesis ; Thioglycolates/urine
    • Abstract:
      A luminescent nanoprobe based on a lanthanide-transition heterometallic metal-organic framework (MOF) is first designed for specific detection of urinary thiodiglycolic acid (TDGA) which is the biomarker of carcinogenic vinyl chloride monomer (VCM) and represents the internal dose of human exposure to VCM. The nanoprobe demonstrates high selectivity to TDGA with about 27.5-fold luminescence enhancement. It also displays excellent sensitivity with a detection limit as low as 89 ng·mL -1 and fast response to TDGA within 4 min, while refraining from the interference of other coexisting species in urine. Such good sensing performance enables the nanoprobe to practically monitor TDGA levels in human urine. Moreover, a portable urine dipstick based on the sensor is developed to conveniently evaluate individuals' intoxication degree of VCM. This fast, sensitive, and selective nanoprobe has promising potential to be a useful tool for point-of-care diagnosis of disease associated with VCM exposure.
    • Accession Number:
      0 (Biomarkers, Tumor)
      0 (Carcinogens)
      0 (Coordination Complexes)
      0 (Luminescent Agents)
      0 (Thioglycolates)
      483M3RG5GW (thiodiacetic acid)
      WD06X94M2D (Vinyl Chloride)
    • Publication Date:
      Date Created: 20170902 Date Completed: 20180307 Latest Revision: 20180307
    • Publication Date:
      20221213
    • Accession Number:
      10.1021/acs.inorgchem.7b01549
    • Accession Number:
      28862435