Maximum home blood pressure is a useful indicator of diabetic nephropathy in patients with type 2 diabetes mellitus: KAMOGAWA-HBP study.

Publisher: Sage Publications Country of Publication: England NLM ID: 101234011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8984 (Electronic) Linking ISSN: 14791641 NLM ISO Abbreviation: Diab Vasc Dis Res Subsets: MEDLINE

Publication: 2009- : London : Sage Publications
Original Publication: Edgbaston, Birmingham, UK : Sherborne Gibbs, c2005-

Blood Pressure* ; Blood Pressure Monitoring, Ambulatory*; Diabetes Mellitus, Type 2/*complications ; Diabetic Nephropathies/*diagnosis; Aged ; Albuminuria/diagnosis ; Albuminuria/etiology ; Albuminuria/physiopathology ; Area Under Curve ; Biomarkers/urine ; Circadian Rhythm ; Creatinine/urine ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/diagnosis ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/physiopathology ; Diabetic Nephropathies/urine ; Early Diagnosis ; Female ; Humans ; Japan ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Risk Factors ; Systole

Objective: Maximum home systolic blood pressure has been shown to predict target organ damage. We aimed to clarify the association between maximum home systolic blood pressure and urine albumin to creatinine ratio, an indicator of early-phase diabetic nephropathy in patients with type 2 diabetes.
Methods: In 1040 patients, we assessed the relationship of mean or maximum home systolic blood pressure and urine albumin to creatinine ratio, and compared the area under the receiver operating characteristic curve of mean or maximum home systolic blood pressure for diabetic nephropathy (urine albumin to creatinine ratio ⩾30 mg/g Cr).
Results: Multivariate linear regression analyses indicated that mean morning systolic blood pressure ( β = 0.010, p < 0.001) and maximum morning systolic blood pressure ( β = 0.008, p < 0.001) were significantly associated with urine albumin to creatinine ratio. Area under the receiver operating characteristic curve (95% confidence interval) for diabetic nephropathy in mean and maximum morning systolic blood pressure was 0.667 (0.634-0.700; p < 0.001) and 0.671 (0.638-0.703; p < 0.001), respectively.
Conclusion: Maximum home systolic blood pressure, as well as mean home systolic blood pressure, was significantly associated with diabetic nephropathy in patients with type 2 diabetes.

Keywords: Maximum home blood pressure; diabetic nephropathy; home blood pressure monitoring; hypertension; multicenter study; type 2 diabetes

0 (Biomarkers)
AYI8EX34EU (Creatinine)

Date Created: 20170819 Date Completed: 20171212 Latest Revision: 20180512

20240628

10.1177/1479164117725477

28819987