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Thrombopoietin receptor agonist switch in adult primary immune thrombocytopenia patients: A retrospective collaborative survey involving 4 Spanish centres.
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- Additional Information
- Source:
Publisher: Blackwell Country of Publication: England NLM ID: 8703985 Publication Model: Print Cited Medium: Internet ISSN: 1600-0609 (Electronic) Linking ISSN: 09024441 NLM ISO Abbreviation: Eur J Haematol Subsets: MEDLINE
- Publication Information:
Publication: <2005->: Oxford : Blackwell
Original Publication: Copenhagen : Munksgaard, c1987-
- Subject Terms:
Drug Substitution*;
Benzoates/
*therapeutic use ;
Hydrazines/
*therapeutic use ;
Purpura, Thrombocytopenic, Idiopathic/
*drug therapy ;
Pyrazoles/
*therapeutic use ;
Receptors, Fc/
*therapeutic use ;
Receptors, Thrombopoietin/
*agonists ;
Recombinant Fusion Proteins/
*therapeutic use ;
Thrombopoietin/
*therapeutic use;
Adolescent ;
Adult ;
Aged ;
Aged, 80 and over ;
Benzoates/
administration & dosage ;
Female ;
Humans ;
Hydrazines/
administration & dosage ;
Male ;
Middle Aged ;
Platelet Count ;
Purpura, Thrombocytopenic, Idiopathic/
blood ;
Purpura, Thrombocytopenic, Idiopathic/
metabolism ;
Pyrazoles/
administration & dosage ;
Receptors, Fc/
administration & dosage ;
Recombinant Fusion Proteins/
administration & dosage ;
Thrombopoietin/
administration & dosage ;
Time Factors ;
Treatment Outcome ;
Young Adult - Abstract:
Objective: To describe the reasons for and result of thrombopoietin receptor agonists (TPO-RA) switching in adult immune thrombocytopenia (ITP) patients of 4 Spanish centres.
Methods: We retrospectively analysed all patients who received sequential treatment with both TPO-RA between 2010 and 2015 recording clinical and biological parameters.
Results: Twenty-six patients were included; 17 received first romiplostim and 9 received first eltrombopag. Reasons for switching were inefficacy (n = 10), patient preference (n = 8), side effects (n = 5) and excessive platelet count fluctuation (n = 3). When the switch was due to inefficacy, 100% of patients who received romiplostim first and 66% who received eltrombopag first responded to the second drug. It is significant that none of the patients who received romiplostim first reached the maximum recommended dose before switching. When the change was due to patient preference or because of side effects, 100% of the patients responded to both TPO-RA. Three patients changed from romiplostim to eltrombopag due to platelet count fluctuation; one did not respond and the fluctuation persisted in the remaining 2 patients. We also found 4 sustained remissions after administering the second TPO-RA, 2 of these with inefficacy of the first drug.
Conclusion: TPO-RA switching is a feasible strategy in different scenarios with high probability of success.
(© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Contributed Indexing:
Keywords: eltrombopag; primary immune thrombocytopenia; romiplostim
- Accession Number:
0 (Benzoates)
0 (Hydrazines)
0 (Pyrazoles)
0 (Receptors, Fc)
0 (Receptors, Thrombopoietin)
0 (Recombinant Fusion Proteins)
9014-42-0 (Thrombopoietin)
GN5XU2DXKV (romiplostim)
S56D65XJ9G (eltrombopag)
- Publication Date:
Date Created: 20170801 Date Completed: 20180521 Latest Revision: 20180521
- Publication Date:
20231215
- Accession Number:
10.1111/ejh.12932
- Accession Number:
28759125
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