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Is cerebral microbleed prevalence relevant as a biomarker in amnestic mild cognitive impairment and mild Alzheimer's disease?
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- Author(s): Rabelo AG;Rabelo AG; Teixeira CV; Teixeira CV; Teixeira CV; Magalhães TN; Magalhães TN; Magalhães TN; Carletti-Cassani AFM; Carletti-Cassani AFM; Amato Filho AC; Amato Filho AC; Joaquim HP; Joaquim HP; Talib LL; Talib LL; Forlenza O; Forlenza O; Ribeiro PA; Ribeiro PA; Ribeiro PA; Secolin R; Secolin R; Secolin R; Lopes-Cendes I; Lopes-Cendes I; Lopes-Cendes I; Cendes F; Cendes F; Cendes F; Balthazar ML; Balthazar ML; Balthazar ML
- Source:
The neuroradiology journal [Neuroradiol J] 2017 Oct; Vol. 30 (5), pp. 477-485. Date of Electronic Publication: 2017 Jul 17.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Sage Publications Country of Publication: United States NLM ID: 101295103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2385-1996 (Electronic) Linking ISSN: 19714009 NLM ISO Abbreviation: Neuroradiol J Subsets: MEDLINE
- Publication Information: Publication: 2015- : Thousand Oaks, CA : Sage Publications
Original Publication: Bologna : Centauro - Subject Terms: Alzheimer Disease/*diagnostic imaging ; Biomarkers/*cerebrospinal fluid ; Cerebral Hemorrhage/*diagnostic imaging ; Cognitive Dysfunction/*diagnostic imaging ; Magnetic Resonance Imaging/*methods; Aged ; Alzheimer Disease/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Amyloid beta-Peptides/genetics ; Apolipoproteins E/cerebrospinal fluid ; Case-Control Studies ; Cerebral Hemorrhage/cerebrospinal fluid ; Cognitive Dysfunction/cerebrospinal fluid ; Female ; Genotype ; Humans ; Male ; Neuropsychological Tests ; Polymerase Chain Reaction ; Prevalence ; tau Proteins/cerebrospinal fluid
- Abstract: Introduction The search for a reliable neuroimaging biomarker in Alzheimer's disease is a matter of intense research. The presence of cerebral microbleeds seems to be a potential biomarker. However, it is not clear if the presence of microbleeds has clinical usefulness to differentiate mild Alzheimer's disease and amnestic mild cognitive impairment from normal aging. We aimed to verify if microbleed prevalence differs among three groups: mild Alzheimer's disease, amnestic mild cognitive impairment due to Alzheimer's disease, and normal controls. Moreover, we studied whether microbleeds were associated with apolipoprotein E allele ɛ4 status, cerebrospinal fluid amyloid-beta, total and phosphorylated tau protein levels, vascular factors, and cognition. Methods Twenty-eight mild Alzheimer's disease patients, 34 with amnestic mild cognitive impairment and 36 cognitively normal elderly subjects underwent: magnetic resonance imaging with a susceptibility-weighted imaging sequence on a 3T scanner, apolipoprotein E genotyping and a full neuropsychological evaluation. Only amnestic mild cognitive impairment and mild Alzheimer's disease underwent cerebrospinal fluid analysis. We compared the groups and verified if microbleeds were predicted by all other variables. Results Mild Alzheimer's disease presented a higher prevalence of apolipoprotein E allele ɛ4 in relation to amnestic mild cognitive impairment and control group. No significant differences were found between groups when considering microbleed presence. Logistic regression tests failed to find any relationship between microbleeds and the variables. We performed three different regression models using different independent variables: Model 1 - amyloid-beta, phosphorylated tau protein, total tau, apolipoprotein E allele ɛ4 status, age, and sex; Model 2 - vascular risk factors, age, and sex; Model 3 - cognitive scores sex, age, and education. Conclusion Although microbleeds might be related to the Alzheimer's disease process, their presence is not a good candidate for a neuroimaging biomarker of the disease, especially in its early phases.
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- Accession Number: 0 (Amyloid beta-Peptides)
0 (Apolipoproteins E)
0 (Biomarkers)
0 (tau Proteins) - Publication Date: Date Created: 20170718 Date Completed: 20171219 Latest Revision: 20240327
- Publication Date: 20240327
- Accession Number: PMC5602341
- Accession Number: 10.1177/1971400917720465
- Accession Number: 28714354
- Source:
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