Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 101540874 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2156-5376 (Electronic) Linking ISSN: 21618313 NLM ISO Abbreviation: Adv Nutr Subsets: MEDLINE
    • Publication Information:
      Publication: 2023- : [New York, NY] : Elsevier
      Original Publication: Bethesda, MD : American Society for Nutrition
    • Subject Terms:
      Biomarkers/*blood ; Cardiovascular Diseases/*blood ; Diabetes Mellitus, Type 2/*blood ; Metabolic Syndrome/*blood ; Obesity/*blood ; Phytochemicals/*administration & dosage; Cardiovascular Diseases/diagnosis ; Diabetes Mellitus, Type 2/diagnosis ; Female ; Humans ; Male ; Metabolic Syndrome/diagnosis ; Obesity/diagnosis ; Phytochemicals/pharmacokinetics ; Polymorphism, Genetic ; Polyphenols/administration & dosage ; Polyphenols/pharmacokinetics ; Randomized Controlled Trials as Topic ; Risk Factors ; Sex Factors
    • Abstract:
      Cardiometabolic disease, comprising cardiovascular diseases, type 2 diabetes, and their associated risk factors including metabolic syndrome and obesity, is the leading cause of death worldwide. Plant foods are rich sources of different groups of bioactive compounds, which might not be essential throughout life but promote health and well-being by reducing the risk of age-related chronic diseases. However, heterogeneity in the responsiveness to bioactive compounds can obscure associations between their intakes and health outcomes, resulting in the hiding of health benefits for specific population groups and thereby limiting our knowledge of the exact role of the different bioactive compounds for health. The heterogeneity in response suggests that some individuals may benefit more than others from the health effects of these bioactive compounds. However, to date, this interindividual variation after habitual intake of plant bioactive compounds has been little explored. The aim of this review is to provide an overview of the existing research that has revealed interindividual variability in the responsiveness to plant-food bioactive compound consumption regarding cardiometabolic outcomes, focusing on polyphenols, caffeine and plant sterols, and the identified potential determinants involved.
      Competing Interests: Author disclosures: DM, CM, AC, AK-R, FT-B, JMO, PK, RDC, and AR-M, no conflicts of interest.
      (© 2017 American Society for Nutrition.)
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    • Contributed Indexing:
      Keywords: biological responsiveness; cardiometabolic health; determinants of interindividual variability; interindividual variability; plant-food bioactives
    • Accession Number:
      0 (Biomarkers)
      0 (Phytochemicals)
      0 (Polyphenols)
    • Publication Date:
      Date Created: 20170716 Date Completed: 20180423 Latest Revision: 20230216
    • Publication Date:
      20240628
    • Accession Number:
      PMC5502866
    • Accession Number:
      10.3945/an.116.013623
    • Accession Number:
      28710143