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Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus: A Pilot MRI Study.
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- Author(s): Chen Z;Chen Z;Chen Z; Zang X; Zang X; Liu M; Liu M; Liu M; Liu M; Liu M; Li J; Li J; Gu Z; Gu Z; Ma L; Ma L
- Source:
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih [Chin Med Sci J] 2017 Jun 10; Vol. 32 (2), pp. 75-2.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Chinese Academy of Medical Sciences Country of Publication: China NLM ID: 9112559 Publication Model: Print Cited Medium: Print ISSN: 1001-9294 (Print) Linking ISSN: 10019294 NLM ISO Abbreviation: Chin Med Sci J Subsets: MEDLINE
- Publication Information: Publication: Beijing : Chinese Academy of Medical Sciences
Original Publication: London ; New York : Taylor & Francis, 1991- - Subject Terms:
- Abstract: Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging (MRI).Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest (ROI) using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness.Results Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM (left: 2.52±0.07 mm; right: 2.51±0.08 mm) were significant thinner than those in the normal controls (left: 2.56±0.09 mm; right: 2.56±0.09 mm) (both P<0.05). Regional cortical thinning in T2DM was demonstrated in the paracentral lobule, postcentral gyrus, lateral occipital gyrus, lingual gyrus, precuneus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and posterior cingulate gyrus, compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course.Conclusion A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.
- Publication Date: Date Created: 20170712 Date Completed: 20171026 Latest Revision: 20171026
- Publication Date: 20231215
- Accession Number: 10.24920/J1001-9294.2017.010
- Accession Number: 28693687
- Source:
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