Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics.

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  • Additional Information
    • Source:
      Publisher: Daedalus Enterprises for the American Association for Respiratory Therapy Country of Publication: United States NLM ID: 7510357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3654 (Electronic) Linking ISSN: 00201324 NLM ISO Abbreviation: Respir Care Subsets: MEDLINE
    • Publication Information:
      Publication: <1983-> : Dallas, TX : Daedalus Enterprises for the American Association for Respiratory Therapy
      Original Publication: Philadelphia : Lippincott, c1971-
    • Subject Terms:
      Metered Dose Inhalers* ; Time Factors*; Albuterol/*administration & dosage ; Bronchodilator Agents/*administration & dosage ; Hydrocarbons, Fluorinated/*administration & dosage; Administration, Inhalation ; Aerosols/administration & dosage ; Drug Administration Schedule ; Drug Delivery Systems ; Humans ; Procaterol/administration & dosage
    • Abstract:
      Background: Albuterol hydrofluoroalkane (HFA) either alone or with a valved holding chamber is used to treat bronchoconstriction. Delays between actuation and inhalation are common. Currently, the recommended interval between actuations of an albuterol HFA is 60 s. Using a shorter interval when multiple actuations are ordered will improve productivity in the hospital setting.
      Methods: We studied aerosol characteristics of albuterol HFA (Ventolin, ProAir, and Proventil) with a cascade impactor calibrated at 30 L/min. We studied pressurized metered-dose inhalers (pMDI) alone, coupled to a nonelectrostatic valved holding chamber, and coupled to the valved holding chamber but introducing a 10-s delay between actuation and measurement. We tested intervals between actuations of 60, 30, and 15 s (not for delay scenario). The variable of most interest was fine-particle mass. Albuterol was measured by spectrophotometer (276 nm).
      Results: Variations in fine-particle mass from 60-s values were < 15% for Ventolin and ProAir for all conditions tested and for Proventil with a valved holding chamber. Variations in fine-particle mass from 60-s values were > 15% for Proventil (pMDI alone with a 30-s interval and pMDI/valved holding chamber with delay and a 30-s interval). Adding a valved holding chamber increased fine-particle mass for all brands (ProAir 7-12%, Ventolin 26-35%, and Proventil 44-47%). The introduction of a 10-s delay reduced fine-particle mass for all brands (ProAir 34-39%, Ventolin 39-42%, and Proventil 27-32%). Comparison of fine-particle mass among brands showed that Proventil was > ProAir > Ventolin.
      Conclusions: Decreasing the interval between actuations from 60 to 30 and 15 s does not seem to affect the aerosol characteristics of ProAir and Ventolin. Although some changes were noticed for Proventil, the pMDI outperformed Ventolin that had the lowest fine-particle mass. The use of a valved holding chamber increased fine-particle mass, but introducing a 10-s delay between actuation and inhalation significantly reduced fine-particle mass.
      (Copyright © 2017 by Daedalus Enterprises.)
    • Comments:
      Comment in: Respir Care. 2017 Sep;62(9):1224-1225. (PMID: 28830986)
    • Contributed Indexing:
      Keywords: aerosol characteristics; delay; drug delivery; metered dose inhaler; particle size; valved holding chamber
    • Accession Number:
      0 (Aerosols)
      0 (Bronchodilator Agents)
      0 (Hydrocarbons, Fluorinated)
      QF8SVZ843E (Albuterol)
      R40P36GDK6 (apaflurane)
      X7I3EMM5K0 (Procaterol)
    • Publication Date:
      Date Created: 20170615 Date Completed: 20180521 Latest Revision: 20191210
    • Publication Date:
      20231215
    • Accession Number:
      10.4187/respcare.05528
    • Accession Number:
      28611228