Vascular reactivity to methoxamine in conscious sinoaortic denervated rats.

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  • Author(s): Moysés MR;Moysés MR; Cabral AM; Vasquez EC
  • Source:
    Pharmacological research communications [Pharmacol Res Commun] 1988 Nov; Vol. 20 (11), pp. 993-9.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0236354 Publication Model: Print Cited Medium: Print ISSN: 0031-6989 (Print) Linking ISSN: 00316989 NLM ISO Abbreviation: Pharmacol Res Commun Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York : Academic Press
    • Subject Terms:
      Denervation*; Blood Pressure/*drug effects ; Heart Rate/*drug effects ; Methoxamine/*pharmacology ; Sinoatrial Node/*physiology; Animals ; Male ; Phenylephrine/pharmacology ; Pressoreceptors/physiology ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic, alpha/drug effects ; Receptors, Adrenergic, alpha/physiology ; Reference Values
    • Abstract:
      Alterations in vascular alpha-adrenoceptor responsiveness following sinoaortic denervation was studied in conscious rats. The arterial hypertension observed in baroreceptor denervated rats decreased progressively during the 30 days of observation. A pressor hyperresponsiveness to methoxamine (10-80 micrograms/kg, iv), was observed 3 to 7 days after baroreceptor denervation followed by a gradual normalization of the vascular reactivity. The results indicate a possible participation of an enhanced alpha 1-adrenoceptor-mediated vasoconstrictor component in the early phase of neurogenic hypertension.
    • Accession Number:
      0 (Receptors, Adrenergic, alpha)
      1WS297W6MV (Phenylephrine)
      HUQ1KC1YLI (Methoxamine)
    • Publication Date:
      Date Created: 19881101 Date Completed: 19890515 Latest Revision: 20190919
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/s0031-6989(88)80127-9
    • Accession Number:
      2853877