Programmable micrometer-sized motor array based on live cells.

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  • Author(s): Xie S;Xie S; Wang X; Jiao N; Tung S; Liu L
  • Source:
    Lab on a chip [Lab Chip] 2017 Jun 13; Vol. 17 (12), pp. 2046-2053.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Print Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge, UK : Royal Society of Chemistry, c2001-
    • Subject Terms:
      Electrophoresis* ; Microfluidic Analytical Techniques* ; Micromanipulation* ; Optics and Photonics*; Cell Movement ; Chlamydomonas reinhardtii ; Equipment Design ; Image Processing, Computer-Assisted
    • Abstract:
      Trapping and transporting microorganisms with intrinsic motility are important tasks for biological, physical, and biomedical applications. However, fast swimming speed makes the manipulation of these organisms an inherently challenging task. In this study, we demonstrated that an optoelectrical technique, namely, optically induced dielectrophoresis (ODEP), could effectively trap and manipulate Chlamydomonas reinhardtii (C. reinhardtii) cells swimming at velocities faster than 100 μm s -1 . Furthermore, live C. reinhardtii cells trapped by ODEP can form a micrometer-sized motor array. The rotating frequency of the cells ranges from 50 to 120 rpm, which can be reversibly adjusted with a fast response speed by varying the optical intensity. Functional flagella have been demonstrated to play a decisive role in the rotation. The programmable cell array with a rotating motion can be used as a bio-micropump to drive the liquid flow in microfludic chips and may shed new light on bio-actuation.
    • Publication Date:
      Date Created: 20170518 Date Completed: 20180725 Latest Revision: 20180725
    • Publication Date:
      20221213
    • Accession Number:
      10.1039/c7lc00017k
    • Accession Number:
      28513721