Genetics of common complex diseases: a view from Iceland.

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  • Author(s): Arnar DO;Arnar DO;Arnar DO; Palsson R; Palsson R; Palsson R
  • Source:
    European journal of internal medicine [Eur J Intern Med] 2017 Jun; Vol. 41, pp. 3-9. Date of Electronic Publication: 2017 Apr 20.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9003220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0828 (Electronic) Linking ISSN: 09536205 NLM ISO Abbreviation: Eur J Intern Med Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : Amsterdam, The Netherlands : Elsevier Science
      Original Publication: Basingstoke, Hampshire, UK : Published by the Macmillan Press on behalf of the European Association of Internal Medicine, c1989-
    • Subject Terms:
      Genetic Predisposition to Disease* ; Genome-Wide Association Study*; Genetics/*trends ; Precision Medicine/*trends; Humans ; Iceland
    • Abstract:
      In the past decade, large scale genotyping has led to discoveries of numerous sequence variants that confer increased risk of many common complex diseases. Interestingly, a substantial proportion of pioneering genetic work has originated from the small nation of Iceland and has been facilitated by an extensive genealogy database. We provide examples of relevant observations made so far in several major disease categories central to internal medicine practice. Some of these findings offer new mechanistic clues into the pathophysiology of common disorders and may suggest novel approaches in diagnosis and drug therapy. However, a number of unresolved issues remain that will be subject of future research, driven by recent advances in high-throughput sequencing of the genome. At the same time, we are ready to begin transforming the abundant existing genetic data into practical clinical knowledge with the aim of improving the delivery of medical care. The era of precision medicine has arrived.
      (Copyright © 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Genealogy; Genetics; Genome-wide association studies; Genomics; Genotyping; Precision medicine; Whole-genome sequencing
    • Publication Date:
      Date Created: 20170424 Date Completed: 20180416 Latest Revision: 20180416
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.ejim.2017.03.018
    • Accession Number:
      28433481