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[Macrocytosis of red blood cells and early arthritis positive for rheumatoid factor such as initial manifestations of a neuroendocrine gastrin-secreting gastric tumor.]
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- Additional Information
- Transliterated Title:
Macrocitosi emaziale ed early arthritis positiva per fattore reumatoide quali manifestazioni di presentazione di un tumore neuroendocrino gastrico gastrina-secernente.
- Source:
Publisher: Il Pensiero Scientifico Editore Country of Publication: Italy NLM ID: 0401271 Publication Model: Print Cited Medium: Internet ISSN: 2038-1840 (Electronic) Linking ISSN: 00341193 NLM ISO Abbreviation: Recenti Prog Med Subsets: MEDLINE
- Publication Information:
Original Publication: Roma : Il Pensiero Scientifico Editore
- Subject Terms:
- Abstract:
Neuroendocrine tumors (NETs) represent uncommon tumors arising from the excessive proliferation of enterochromaffin-like (ECL) cells (so-called Kulchitsky cell). Gastric NETs (GNET) represent less than 2% of all NETs and less than 1% of all stomach neoplasms. In particular, gastric NETs type 1 (associated to chronic atrophic gastritis and hypergastrinaemia) is the more frequent one, accounting for 70-80% of all GNET. A macrocytic anemia is a frequent manifestation of GNET type 1. The possibility that macrocytic anemia appear during therapy with methotrexate (MTX) is widely documented. Similarly, MTX can determine gastric atrophy. We describe the case of a patient with rheumatoid factor-positive early arthritis (EA) in which the appearance of macrocytic anemia during treatment with MTX led to the recognition of a GNET type 1, until then asymptomatic. The endoscopic eradication of polypoid formations forming the GNET, the immediate suspension of MTX and therapy with octreotide long-action determined the complete remission of arthritis. This remission is maintained until today. According to our knowledge, the possibility that an EA may represent a paraneoplastic manifestation of GNET has never been described.
- Accession Number:
0 (Antimetabolites, Antineoplastic)
0 (Antineoplastic Agents, Hormonal)
0 (Gastrins)
9009-79-4 (Rheumatoid Factor)
RWM8CCW8GP (Octreotide)
YL5FZ2Y5U1 (Methotrexate)
- Publication Date:
Date Created: 20170412 Date Completed: 20181003 Latest Revision: 20181202
- Publication Date:
20240829
- Accession Number:
10.1701/2656.27238
- Accession Number:
28398409
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