Aqueous ionic liquids and their effects on protein structures: an overview on recent theoretical and experimental results.

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  • Author(s): Smiatek J;Smiatek J
  • Source:
    Journal of physics. Condensed matter : an Institute of Physics journal [J Phys Condens Matter] 2017 Jun 14; Vol. 29 (23), pp. 233001. Date of Electronic Publication: 2017 Apr 11.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: IOP Pub Country of Publication: England NLM ID: 101165248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1361-648X (Electronic) Linking ISSN: 09538984 NLM ISO Abbreviation: J Phys Condens Matter Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bristol, UK : IOP Pub., c1989-
    • Subject Terms:
      Protein Conformation* ; Protein Denaturation*; Proteins/*chemistry; Ionic Liquids/chemistry ; Water/chemistry
    • Abstract:
      Ionic liquids (ILs) are used in a variety of technological and biological applications. Recent experimental and simulation results reveal the influence of aqueous ionic liquids on the stability of protein and enzyme structures. Depending on different parameters like the concentration and the ion composition, one can observe distinct stabilization or denaturation mechanisms for various ILs. In this review, we summarize the main findings and discuss the implications with regard to molecular theories of solutions and specific ion effects. A preferential binding model is introduced in order to discuss protein-IL effects from a statistical mechanics perspective. The value of the preferential binding coefficient determines the strength of the ion influence and indicates a shift of the chemical equilibrium either to the native or the denatured state of the protein. We highlight the role of water in order to explain the self-association behavior of the IL species and discuss recent experimental and simulation results in the light of the observed binding effects.
    • Accession Number:
      0 (Ionic Liquids)
      0 (Proteins)
      059QF0KO0R (Water)
    • Publication Date:
      Date Created: 20170412 Date Completed: 20180208 Latest Revision: 20180208
    • Publication Date:
      20240829
    • Accession Number:
      10.1088/1361-648X/aa6c9d
    • Accession Number:
      28398214