Effects of metronidazole combined probiotics over metronidazole alone for the treatment of bacterial vaginosis: a meta-analysis of randomized clinical trials.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Tan H;Tan H; Fu Y; Fu Y; Yang C; Yang C; Ma J; Ma J
  • Source:
    Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2017 Jun; Vol. 295 (6), pp. 1331-1339. Date of Electronic Publication: 2017 Apr 06.
  • Publication Type:
    Journal Article; Meta-Analysis; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8710213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0711 (Electronic) Linking ISSN: 09320067 NLM ISO Abbreviation: Arch Gynecol Obstet Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: München : Springer International, c1987-
    • Subject Terms:
      Metronidazole/*therapeutic use ; Probiotics/*therapeutic use ; Vaginosis, Bacterial/*drug therapy; Administration, Intravaginal ; Drug Therapy, Combination ; Female ; Humans ; Hydrogen-Ion Concentration ; Metronidazole/administration & dosage ; Probiotics/administration & dosage ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Vaginosis, Bacterial/microbiology
    • Abstract:
      Object: To evaluate the curative effect of metronidazole combined probiotics over metronidazole alone in the treatment of BV.
      Methods: We are searching randomized controlled trials on major online databases including PubMed, Science Direct, and Cochrane Database between 1990 and 2015. The primary outcome measure was the cure rate of BV. Cochran's Chi-square test (Q test) was used to test for heterogeneity among trials, and the I 2 index. We used mixed-effects modeling for parameters of the summary hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs).
      Results: Analysis suggests the cure rate of BV [RR = 1.12, 95% CI (0.94-1.32), p = 0.20], and the I 2 index was 83%. The value of I 2 index decreased to 16% after removing the study of Anukam et al., and Amsel 1.04 (95% CI 0.96-1.13) (p = 0.35), Nugent 1.02 (95% CI 0.94-1.11), short-term 1.01 (95% CI 0.93-1.10) (p = 0.79), long-term 1.06 (95% CI 0.98-1.14) (p = 0.13), Europe 1.06 (95% CI 0.95-1.19) (p = 0.32), Non-Europe 0.99 (95% CI 0.94-1.05) (p = 0.83). When the two same groups data were combined, respectively, the RRs for all studies were the same as 1.03 (95% CI 0.96-1.09) (p = 0.42) showing that there is not statistically significant in relevant stratums.
      Conclusion: The result has showed an overall little significance for the efficacy of metronidazole combined probiotics over metronidazole alone for the treatment of BV. We need more further studies to provide enough evidence to confirm the benefits of probiotics in the treatment of BV.
    • Contributed Indexing:
      Keywords: Bacterial vaginosis; Meta-analysis; Metronidazole; Probiotics
    • Accession Number:
      140QMO216E (Metronidazole)
    • Publication Date:
      Date Created: 20170408 Date Completed: 20171103 Latest Revision: 20220409
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00404-017-4366-0
    • Accession Number:
      28386675