Intrahemispheric Perfusion in Chronic Stroke-Induced Aphasia.

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  • Additional Information
    • Source:
      Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 100883417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1687-5443 (Electronic) Linking ISSN: 16875443 NLM ISO Abbreviation: Neural Plast Subsets: MEDLINE
    • Publication Information:
      Publication: New York, NY : Hindawi Pub. Corp
      Original Publication: Patrington, East Yorkshire, U.K. : Freund & Pettman, c1998-
    • Subject Terms:
      Aphasia/*diagnostic imaging ; Cerebrovascular Circulation/*physiology ; Cerebrum/*diagnostic imaging ; Cerebrum/*physiology ; Stroke/*diagnostic imaging; Adult ; Aged ; Aphasia/etiology ; Cerebrum/blood supply ; Chronic Disease ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Stroke/complications
    • Abstract:
      Stroke-induced alterations in cerebral blood flow (perfusion) may contribute to functional language impairments and recovery in chronic aphasia. Using MRI, we examined perfusion in the right and left hemispheres of 35 aphasic and 16 healthy control participants. Across 76 regions (38 per hemisphere), no significant between-subjects differences were found in the left, whereas blood flow in the right was increased in the aphasic compared to the control participants. Region-of-interest (ROI) analyses showed a varied pattern of hypo- and hyperperfused regions across hemispheres in the aphasic participants; however, there were no significant correlations between perfusion values and language abilities in these regions. These patterns may reflect autoregulatory changes in blood flow following stroke and/or increases in general cognitive effort, rather than maladaptive language processing. We also examined blood flow in perilesional tissue, finding the greatest hypoperfusion close to the lesion (within 0-6 mm), with greater hypoperfusion in this region compared to more distal regions. In addition, hypoperfusion in this region was significantly correlated with language impairment. These findings underscore the need to consider cerebral perfusion as a factor contributing to language deficits in chronic aphasia as well as recovery of language function.
      Competing Interests: The authors declare that they have no competing interests.
    • References:
      Neuropsychologia. 2010 Sep;48(11):3211-27. (PMID: 20603138)
      Eur J Neurosci. 2003 Oct;18(7):1950-62. (PMID: 14622227)
      ISRN Neurol. 2012;2012:786872. (PMID: 23320190)
      Ann N Y Acad Sci. 2005 Dec;1064:149-61. (PMID: 16394154)
      Magn Reson Med. 2008 Dec;60(6):1488-97. (PMID: 19025913)
      Brain. 2014 Oct;137(Pt 10):2632-48. (PMID: 24974382)
      Stroke. 2001 Sep;32(9):2179-84. (PMID: 11546914)
      Stroke. 1995 Nov;26(11):2135-44. (PMID: 7482662)
      Curr Neurol Neurosci Rep. 2008 Nov;8(6):475-83. (PMID: 18957184)
      Neuroimage Clin. 2012 Nov 30;2:174-83. (PMID: 24179769)
      Magn Reson Med. 2004 Sep;52(3):679-82. (PMID: 15334591)
      Brain Lang. 2013 Apr;125(1):11-27. (PMID: 23454070)
      Hum Brain Mapp. 2015 Apr;36(4):1620-36. (PMID: 25469481)
      Brain Lang. 2007 Aug;102(2):165-75. (PMID: 16757020)
      Neuroimaging Clin N Am. 2005 Aug;15(3):697-720, xii-xiii. (PMID: 16360598)
      Brain Lang. 2011 Jul;118(1-2):40-50. (PMID: 21459427)
      Neuroimage Clin. 2015 Mar 24;8:87-94. (PMID: 26106531)
      Stroke. 1977 Jan-Feb;8(1):51-7. (PMID: 13521)
      Brain. 2006 Jun;129(Pt 6):1371-84. (PMID: 16638796)
      Stroke. 2004 Mar;35(3):758-63. (PMID: 14963280)
      Neuroimage. 2004;23 Suppl 1:S220-33. (PMID: 15501093)
      J Neurosci. 2007 Apr 11;27(15):4101-9. (PMID: 17428988)
      J Cereb Blood Flow Metab. 1985 Mar;5(1):65-9. (PMID: 3871783)
      Neuroimage. 2010 Jul 1;51(3):995-1005. (PMID: 20211268)
      Can J Neurol Sci. 1995 Nov;22(4):257-63. (PMID: 8599767)
      Neuroimage. 2007 Jun;36(2):322-31. (PMID: 17467297)
      Neuroscientist. 2003 Feb;9(1):64-75. (PMID: 12580341)
      Adv Neurol. 1997;73:207-27. (PMID: 8959216)
      Behav Neurol. 2011;24(2):117-22. (PMID: 21606572)
      Nat Rev Neurosci. 2004 Oct;5(10):813-9. (PMID: 15378041)
      Magn Reson Med. 1990 Jul;15(1):152-7. (PMID: 2374495)
      Neuroimage. 2012 Apr 2;60(2):854-63. (PMID: 22227052)
      Curr Opin Neurobiol. 1999 Dec;9(6):740-7. (PMID: 10607636)
      Neurology. 2006 Oct 10;67(7):1215-20. (PMID: 17030755)
      Magn Reson Med. 2015 Jan;73(1):102-16. (PMID: 24715426)
      Expert Rev Neurother. 2003 May;3(3):373-80. (PMID: 19810904)
      Stroke. 2002 Dec;33(12):2985-91. (PMID: 12468801)
      Stroke. 2004 Feb;35(2):554-9. (PMID: 14739418)
      Magn Reson Imaging. 2012 Dec;30(10):1409-15. (PMID: 22789842)
      IEEE Trans Med Imaging. 2003 Jan;22(1):62-74. (PMID: 12703760)
      Ann Intern Med. 1987 Jan;106(1):27-34. (PMID: 3491558)
      Ann Neurol. 2008 Mar;63(3):272-87. (PMID: 18383072)
      Ann Neurol. 1991 Jan;29(1):63-71. (PMID: 1996881)
      Aphasiology. 2002;16(9):873-883. (PMID: 30906100)
      Magn Reson Imaging. 2008 Feb;26(2):261-9. (PMID: 17826940)
      Annu Rev Psychol. 2009;60:173-96. (PMID: 19035823)
      Neuroimage. 2016 Jan 1;124(Pt B):1131-1136. (PMID: 26032888)
      Neuroscience. 2006;139(4):1495-506. (PMID: 16516395)
    • Grant Information:
      P50 DC012283 United States DC NIDCD NIH HHS
    • Publication Date:
      Date Created: 20170331 Date Completed: 20170920 Latest Revision: 20240324
    • Publication Date:
      20240324
    • Accession Number:
      PMC5357554
    • Accession Number:
      10.1155/2017/2361691
    • Accession Number:
      28357141