Clinical correlation of imaging findings in congenital cranial dysinnervation disorders involving abducens nerve.

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  • Additional Information
    • Source:
      Publisher: Medknow Publications Country of Publication: India NLM ID: 0405376 Publication Model: Print Cited Medium: Internet ISSN: 1998-3689 (Electronic) Linking ISSN: 03014738 NLM ISO Abbreviation: Indian J Ophthalmol Subsets: MEDLINE
    • Publication Information:
      Publication: Mumbai : Medknow Publications
      Original Publication: Bombay : All-India Ophthalmological Society
    • Subject Terms:
      Abnormalities, Multiple*; Abducens Nerve Diseases/*diagnosis ; Duane Retraction Syndrome/*diagnosis ; Magnetic Resonance Imaging/*methods ; Mobius Syndrome/*diagnosis ; Oculomotor Muscles/*innervation ; Orbit/*diagnostic imaging; Abducens Nerve/diagnostic imaging ; Abducens Nerve Diseases/congenital ; Humans ; Imaging, Three-Dimensional ; Oculomotor Muscles/diagnostic imaging ; Pilot Projects
    • Abstract:
      Purpose: High-resolution magnetic resonance imaging (MRI) of intracranial parts of sixth nerve and seventh nerve and the extraocular muscles (EOMs) in orbit to correlate the clinical characteristics in patients with two special forms of strabismus in congenital cranial dysinnervation disorders which are Duane's retraction syndrome (DRS) and Mobius syndrome.
      Materials and Methods: Morphological analysis by 3T MRI of orbit (using surface coils) and brain (using 32 channel head coil) was performed on 6 patients with clinical DRS (1 bilateral), 2 cases with Mobius syndrome, and 1 case with congenital sixth nerve palsy. These were compared with findings in five controls.
      Results: We observed absence/hypoplasia of sixth nerve in five out of seven eyes with DRS (71.42%), anomalous course in one eye, sixth and seventh nerve absence/hypoplasia in affected eyes with Mobius syndrome and bilateral absence/hypoplasia of the sixth nerve in congenital sixth nerve palsy. For EOMs we calculated maximum diameter, area, and circumference of muscles using Osirix software, and noticed significant hypoplasia of lateral rectus in comparison to controls (P < 0.001).
      Conclusions: MRI gives useful information regarding confirmation of clinical diagnosis and its neurological anomalies in complex cases and helps to plan tailor made surgical management.
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    • Publication Date:
      Date Created: 20170328 Date Completed: 20170816 Latest Revision: 20181113
    • Publication Date:
      20240829
    • Accession Number:
      PMC5381296
    • Accession Number:
      10.4103/ijo.IJO_1013_15
    • Accession Number:
      28345573