Highly Modular Bioluminescent Sensors for Small Molecules and Proteins.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Point-of-Care Systems*; Biosensing Techniques/*methods ; Drug Monitoring/*methods ; Luminescent Measurements/*methods ; Pharmaceutical Preparations/*analysis ; Proteins/*analysis; Animals ; Biosensing Techniques/instrumentation ; Drug Monitoring/instrumentation ; Humans ; Luminescent Measurements/instrumentation ; Models, Molecular
    • Abstract:
      Obtaining patient-specific information through the quantification of small molecules and proteins in bodily fluids is essential for personalized therapies. Point-of-care (POC) diagnostic devices hold the promise of delivering such benefit to a wide range of patients. However, there is a lack of enabling technology, as the majority of newly developed POC devices focus on the same underlying core technologies. Here we provide an overview of a new technology based on highly modular bioluminescent sensors that enables the quantification of small molecules and proteins at the POC with low-cost devices.
      (© 2017 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bioluminescence; Biosensors; Point-of-care device; Protein engineering
    • Accession Number:
      0 (Pharmaceutical Preparations)
      0 (Proteins)
    • Publication Date:
      Date Created: 20170325 Date Completed: 20170821 Latest Revision: 20180928
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/bs.mie.2017.01.005
    • Accession Number:
      28336070