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Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats.
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- Author(s): Yoshida K;Yoshida K; Ohta Y; Ohta Y; Kawate N; Kawate N; Takahashi M; Takahashi M; Inaba T; Inaba T; Hatoya S; Hatoya S; Morii H; Morii H; Takahashi K; Takahashi K; Ito M; Ito M; Tamada H; Tamada H
- Source:
Andrologia [Andrologia] 2018 Feb; Vol. 50 (1). Date of Electronic Publication: 2017 Mar 10.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Blackwell Pub Country of Publication: Germany NLM ID: 0423506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0272 (Electronic) Linking ISSN: 03034569 NLM ISO Abbreviation: Andrologia Subsets: MEDLINE
- Publication Information: Publication:
: Berlin : Blackwell Pub.
Original Publication: Berlin, Grosse - Subject Terms: Lepidium*; Aging/*drug effects ; Leydig Cells/*drug effects ; Plant Extracts/*pharmacology ; Testosterone/*biosynthesis; Aging/metabolism ; Animals ; Chorionic Gonadotropin/pharmacology ; Hydroxycholesterols/pharmacology ; Leydig Cells/metabolism ; Male ; Pregnenolone/pharmacology ; Rats ; Testosterone/blood
- Abstract: This study examined whether feeding hydroalcoholic extract of Lepidium meyenii (maca) to 8-week-old (sexually maturing) or 18-week-old (mature) male rats for more than a half year affects serum testosterone concentration and testosterone production by Leydig cells cultured with hCG, 22R-hydroxycholesterol or pregnenolone. Testosterone concentration was determined in the serum samples obtained before and 6, 12, 18 and 24 weeks after the feeding, and it was significantly increased only at the 6 weeks in the group fed with the maca extract to maturing rats when it was compared with controls. Testosterone production by Leydig cells significantly increased when cultured with hCG by feeding the maca extract to maturing rats for 27 weeks (35 weeks of age) and when cultured with 22R-hydroxycholesterol by feeding it to mature rats for 30 weeks (48 weeks of age). Overall testosterone production by cultured Leydig cells decreased to about a half from 35 to 48 weeks of age. These results suggest that feeding the maca extract for a long time to male rats may enhance the steroidogenic ability of Leydig cells to alleviate its decline with ageing, whereas it may cause only a transient increase in blood testosterone concentration in sexually maturing male rats.
(© 2017 Blackwell Verlag GmbH.) - Contributed Indexing: Keywords: Leydig cells; ageing; maca; rat; testosterone
- Accession Number: 0 (Chorionic Gonadotropin)
0 (Hydroxycholesterols)
0 (Plant Extracts)
17711-16-9 (22-hydroxycholesterol)
3XMK78S47O (Testosterone)
73R90F7MQ8 (Pregnenolone) - Publication Date: Date Created: 20170316 Date Completed: 20180201 Latest Revision: 20180201
- Publication Date: 20240628
- Accession Number: 10.1111/and.12803
- Accession Number: 28295471
- Source:
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