Impact of oocyte donation on perinatal outcome in twin pregnancies.

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  • Additional Information
    • Source:
      Publisher: Elsevier for the American Society for Reproductive Medicine Country of Publication: United States NLM ID: 0372772 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-5653 (Electronic) Linking ISSN: 00150282 NLM ISO Abbreviation: Fertil Steril Subsets: MEDLINE
    • Publication Information:
      Publication: New York. NY : Elsevier for the American Society for Reproductive Medicine
      Original Publication: New York, Hoeber.
    • Subject Terms:
      Pregnancy, Twin*; Infertility/*therapy ; Oocyte Donation/*adverse effects ; Postpartum Hemorrhage/*etiology ; Pre-Eclampsia/*etiology; Academic Medical Centers ; Adolescent ; Adult ; Birth Weight ; Embryo Transfer/adverse effects ; Female ; Fertility ; Fertilization in Vitro/adverse effects ; Gestational Age ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infertility/diagnosis ; Infertility/physiopathology ; Live Birth ; Middle Aged ; Perinatal Mortality ; Pregnancy ; Premature Birth/etiology ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Young Adult
    • Abstract:
      Objective: To compare perinatal outcomes of twin pregnancies after oocyte donation (OD), in vitro fertilization (IVF) with autologous oocyte (AO), and non-IVF conception.
      Design: Five-year retrospective cohort study.
      Setting: Tertiary university medical center.
      Patient(s): All patients with twin pregnancies who gave birth after 24 weeks of gestation. The outcomes of 102 OD twin pregnancies were compared with those of 201 AO and 369 non-IVF twin pregnancies.
      Intervention(s): None.
      Main Outcome Measure(s): Obstetrical complications (pregnancy-induced hypertensive disorders, gestational diabetes, cholestasis, preterm rupture of membranes, mode of delivery, and postpartum hemorrhage) and neonatal outcome (preterm birth, low birth weight, neonatal hospitalization, and perinatal mortality).
      Result(s): There was an increased incidence of preeclampsia (OD 26.5%, AO 7.0%, non-IVF 8.7%) and postpartum hemorrhage (OD 23.5%, AO 12.4%, non-IVF 7.6%) in the OD group compared with the AO and non-IVF groups. After adjustment for confounding factors, including maternal age and chorionicity, the risk of preeclampsia remained higher in the OD group, as did the risk of postpartum hemorrhage. The OD group was not at higher risk than the AO and non-IVF groups for other complications, particularly for preterm birth or low birth weight.
      Conclusion(s): OD twin pregnancies are associated with a higher risk of preeclampsia and postpartum hemorrhage than AO and non-IVF twin pregnancies.
      (Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Oocyte donation; assisted reproduction technology; postpartum hemorrhage; preeclampsia; twin gestation
    • Publication Date:
      Date Created: 20170312 Date Completed: 20170605 Latest Revision: 20170605
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.fertnstert.2017.01.019
    • Accession Number:
      28283263