Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons.

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  • Additional Information
    • Source:
      Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE
    • Publication Information:
      Publication: <2003-> : Hoboken, N.J. : Wiley-Liss
      Original Publication: Philadelphia Wistar Institute of Anatomy and Biology
    • Subject Terms:
      Olfactory Bulb/*cytology ; RNA, Messenger/*metabolism ; RNA-Binding Proteins/*genetics ; RNA-Binding Proteins/*metabolism ; Sensory Receptor Cells/*classification ; Sensory Receptor Cells/*metabolism; Animals ; Axons/metabolism ; Calmodulin/genetics ; Calmodulin/metabolism ; Carbonic Anhydrase II/genetics ; Carbonic Anhydrase II/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 2/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 2/metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Neural Cell Adhesion Molecules/genetics ; Neural Cell Adhesion Molecules/metabolism ; Olfactory Marker Protein/genetics ; Olfactory Marker Protein/metabolism
    • Abstract:
      Local protein synthesis in mature axons may play a role in synaptic plasticity, axonal arborization, or functional diversity of the circuit. To gain insight into this question, we investigated the axonal localization of translational regulators and associated mRNAs in five parallel olfactory circuits, four in the main olfactory bulb and one in the accessory olfactory bulb. Axons in all four main olfactory bulb circuits exhibited axonal localization of Fragile X granules (FXGs), structures that comprise ribosomes, mRNA, and RNA binding proteins including Fragile X mental retardation protein (FMRP) and the related protein FXR2P. In contrast, FXGs were not seen in axons innervating the accessory olfactory bulb. Similarly, axons innervating the main olfactory bulb, but not the accessory olfactory bulb, contained the FXG-associated mRNA Omp (olfactory marker protein). This differential localization was not explained by circuit-dependent differences in expression of FXG components or Omp, suggesting that other factors must regulate their axonal transport. The specificity of this transport was highlighted by the absence from olfactory axons of the calmodulin transcript Calm1, which is highly expressed in peripheral olfactory neurons at levels equivalent to Omp. Regulation of axonal translation by FMRP may shape the structure and function of the axonal arbor in mature sensory neurons in the main olfactory system but not in the accessory olfactory system.
      (© 2017 Wiley Periodicals, Inc.)
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    • Grant Information:
      R00 MH090237 United States MH NIMH NIH HHS; R01 HD052083 United States HD NICHD NIH HHS
    • Contributed Indexing:
      Keywords: FXR2P; RRID: AB_2149710; RRID: AB_306884; RRID: AB_398856; RRID: AB_476964; RRID: AB_653928; RRID: AB_664696; olfactory epithelium; olfactory marker protein; olfactory sensory neuron; vomeronasal organ; vomeronasal sensory neuron
    • Accession Number:
      0 (Calm1 protein, mouse)
      0 (Calmodulin)
      0 (FXR2 protein, mouse)
      0 (Ncam2 protein, mouse)
      0 (Neural Cell Adhesion Molecules)
      0 (Olfactory Marker Protein)
      0 (Omp protein, mouse)
      0 (RNA, Messenger)
      0 (RNA-Binding Proteins)
      EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 2)
      EC 3.1.4.17 (Pde2a protein, mouse)
      EC 4.2.1.- (Carbonic Anhydrase II)
    • Publication Date:
      Date Created: 20170308 Date Completed: 20170825 Latest Revision: 20181113
    • Publication Date:
      20240829
    • Accession Number:
      PMC5820109
    • Accession Number:
      10.1002/cne.24199
    • Accession Number:
      28266018