Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

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  • Additional Information
    • Corporate Authors:
      MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria, VA : American Diabetes Association
      Original Publication: [New York, American Diabetes Association]
    • Subject Terms:
      Black or African American/*genetics ; Diabetes Mellitus, Type 2/*genetics ; Hispanic or Latino/*genetics ; KCNQ1 Potassium Channel/*genetics ; Transcription Factor 7-Like 2 Protein/*genetics; Adolescent ; Adult ; Aged ; Case-Control Studies ; Diabetes Mellitus, Type 2/complications ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Genotyping Techniques ; Haplotypes ; Humans ; Linear Models ; Male ; Middle Aged ; Obesity/complications ; Polymorphism, Single Nucleotide ; Risk Assessment ; United States ; Young Adult
    • Abstract:
      Few genome-wide association studies (GWAS) of type 2 diabetes (T2D) have been conducted in U.S. Hispanics/Latinos of diverse backgrounds who are disproportionately affected by diabetes. We conducted a GWAS in 2,499 T2D case subjects and 5,247 control subjects from six Hispanic/Latino background groups in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Our GWAS identified two known loci ( TCF7L2 and KCNQ1) reaching genome-wide significance levels. Conditional analysis on known index single nucleotide polymorphisms (SNPs) indicated an additional independent signal at KCNQ1 , represented by an African ancestry-specific variant, rs1049549 (odds ratio 1.49 [95% CI 1.27-1.75]). This association was consistent across Hispanic/Latino background groups and replicated in the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium. Among 80 previously known index SNPs at T2D loci, 66 SNPs showed consistency with the reported direction of associations and 14 SNPs significantly generalized to the HCHS/SOL. A genetic risk score based on these 80 index SNPs was significantly associated with T2D (odds ratio 1.07 [1.06-1.09] per risk allele), with a stronger effect observed in nonobese than in obese individuals. Our study identified a novel independent signal suggesting an African ancestry-specific allele at KCNQ1 for T2D. Associations between previously identified loci and T2D were generally shown in a large cohort of U.S. Hispanics/Latinos.
      (© 2017 by the American Diabetes Association.)
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    • Grant Information:
      HHSN268201300005C United States HL NHLBI NIH HHS; N01HC65236 United States HL NHLBI NIH HHS; N01HC65235 United States HL NHLBI NIH HHS; UL1 TR000124 United States TR NCATS NIH HHS; N01HC65234 United States HL NHLBI NIH HHS; P30 DK020541 United States DK NIDDK NIH HHS; K01 HL130609 United States HL NHLBI NIH HHS; P30 DK063491 United States DK NIDDK NIH HHS; K01 HL129892 United States HL NHLBI NIH HHS; N01HC65233 United States HL NHLBI NIH HHS; R01 DK066358 United States DK NIDDK NIH HHS; N01HC65237 United States HL NHLBI NIH HHS; U54 TR000123 United States TR NCATS NIH HHS
    • Accession Number:
      0 (KCNQ1 Potassium Channel)
      0 (KCNQ1 protein, human)
      0 (TCF7L2 protein, human)
      0 (Transcription Factor 7-Like 2 Protein)
    • Publication Date:
      Date Created: 20170304 Date Completed: 20170818 Latest Revision: 20240213
    • Publication Date:
      20240213
    • Accession Number:
      PMC5399610
    • Accession Number:
      10.2337/db16-1150
    • Accession Number:
      28254843