[Allogeneic hematopoietic stem cell transplantation in Hungary].

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  • Additional Information
    • Transliterated Title:
      Allogén vérképzőőssejt-átültetés Magyarországon.
    • Source:
      Publisher: Akademiai Kiado Country of Publication: Hungary NLM ID: 0376412 Publication Model: Print Cited Medium: Print ISSN: 0030-6002 (Print) Linking ISSN: 00306002 NLM ISO Abbreviation: Orv Hetil Subsets: MEDLINE
    • Publication Information:
      Publication: 2007- : Budapest : Akademiai Kiado
      Original Publication: Pest : Markusovszky Lajos
    • Subject Terms:
      Hematopoietic Stem Cell Transplantation/*statistics & numerical data ; Leukemia, Myeloid, Acute/*therapy ; Myelodysplastic Syndromes/*therapy; Allografts ; Disease-Free Survival ; Female ; Histocompatibility Testing ; Humans ; Hungary ; Male ; Retrospective Studies ; Survival Rate
    • Abstract:
      Introduction and Aim: The publication summarizes the 2548 stem cell transplantations performed in the period of 1993-2015 in Szent Laszló Hospital, Budapest and provides a detailed discussion of the 425 allogeneic transplantations during 2007-2013.
      Method: The analysis explains the major steps of the evolution of allogeneic stem cell transplantation and compares the results of the unique Hungarian allogeneic center.
      Results: The significant shift in the transplantation indications from chronic myeloid leukemia to myelodysplastic syndromes and the rising age of the recipients are in line with world wide tendencies. The latter one is the consequence of the introduction and improvement of the concept of reduced intensity conditioning regimens, originally arising from the idea of Endre Kelemen. The most limiting factor, the donor availability seems to be resolved with the use of a new immunomodulating regimen, the application of posttransplantation cyclophosphamide, which allows the transplantation through HLA barriers with haploidentical family donors with comparable results to the HLA matched volunteer unrelated donors. The above mentioned tendencies result the wider use of allogeneic stem cell transplantation less dependent from recipient age, comorbidities and even donor availability.
      Conclusions: The publication highlights the need of expanding the stem cell transplantation budget and the involvement of new centers in Hungary in allogeneic of stem cell transplantation. Orv. Hetil., 2017, 158(8), 291-297.
    • Contributed Indexing:
      Keywords: allogeneic stem cell transplantation; allogén transzplantáció; hematology; hematológia
    • Publication Date:
      Date Created: 20170221 Date Completed: 20170803 Latest Revision: 20170803
    • Publication Date:
      20231215
    • Accession Number:
      10.1556/650.2017.30648
    • Accession Number:
      28218567